- ►diabetesjournals.org YS Aulchenko, J Pullen, WP Kloosterman, M … - Diabetes, 2007 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We investigated the region in a young genetically isolated
population by genotyping 34 single nucleotide polymorphisms (SNPs) in 78 case subjects and
101 control subjects. Two SNPs were selected and followed up in two cohorts. The first ... Cited by 9 - Related articles - BL Direct - All 3 versions
KA Fawcett, N Grimsey, RJF Loos, E Wheeler, A Daly, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Loss of lipin 1 activity causes lipodystrophy and insulin resistance in the fld
mouse, and LPIN1 expression and common genetic variation were recently suggested to influence
adiposity and insulin sensitivity in humans. We aimed to conduct a comprehensive ... Cited by 3 - Related articles - All 6 versions
KL Ong, RYH Leung, LYF Wong, SS Cherny, PC … - American journal of …, 2008 - nature.com None of the tagging SNPs were found to be associated with hypertension after correcting for
multiple testing, although carriers of the minor allele of rs10520097 had nominally lower odds
for hypertension (P = 0.014). After excluding subjects who were on antihypertensive ... Cited by 4 - Related articles - All 4 versions
ES Kang, SE Park, SJ Han, SH Kim, CM Nam, CW … - Molecular genetics and …, 2008 - Elsevier Lipin1 protein, a product of the LPIN1 gene, is required for normal adipose tissue development
and metabolism. Lipin1 deficiency results in immature adipocyte development in cases of mouse
fatty liver dystrophy and human lipodystrophy. Recently, pioglitazone has been reported ... Cited by 5 - Related articles - All 3 versions
N Grimsey, GS Han, L O'Hara, JJ Rochford, GM … - Journal of Biological …, 2008 - ASBMB Lipins are the founding members of a novel family of Mg 2+ -dependent phosphatidate phosphatases
(PAP1 enzymes) that play key roles in fat metabolism and lipid biosynthesis. Despite their
importance, there is still little information on how their activity is regulated. Here we ... Cited by 10 - Related articles - All 9 versions
- ►ahajournals.org Z Chen, MC Gropler, J Norris, JC Lawrence Jr … - … , and vascular biology, 2008 - Am Heart Assoc Methods and Results— Rates of TAG synthesis were not impaired in hepatocytes isolated from
adult lipin 1–deficient (fld) mice and were actually increased in 14-day-old fld mice.
Additionally, compared to littermate controls, VLDL-TAG secretion rates were markedly ... Cited by 6 - Related articles - All 8 versions
- ►jlr.org B Manmontri, M Sariahmetoglu, J Donkor, MB … - The Journal of Lipid …, 2008 - ASBMB Glucocorticoids (GCs) increase hepatic phosphatidate phosphatase (PAP1) activity. This is important
in enhancing the liver's capacity for storing fatty acids as triacylglycerols (TAGs) that can be used
subsequently for β-oxidation or VLDL secretion. PAP1 catalyzes the conversion of ... Cited by 13 - Related articles - All 4 versions
[CITATION] Homozygous mutations in LPIN2 are responsible for the syndrome of chronic …
K Reue, J Donkor - Diabetes, 2007 - Am Diabetes Assoc Type 2 diabetes was once referred to as a “geneticist's nightmare” (1) due to difficulties stemming
from the nature of the disease and the strategies available for genetic analysis. Two key genetic
approaches previously utilized—linkage analysis and candidate gene association ... Cited by 2 - Related articles - BL Direct - All 3 versions
- ►endojournals.org J Donkor, LM Sparks, H Xie, SR Smith, K … - Journal of Clinical …, 2008 - Endocrine Soc Results: In healthy young men, lipin-1 expression was positively correlated with insulin sensitivity
(R 2 = 0.22; P < 0.01), insulin-stimulated respiratory quotient (R 2 = 0.16; P < 0.01), and maximal
oxygen consumption during exercise (R 2 = 0.16; P < 0.01). Lipin-1 mRNA levels were ... Cited by 8 - Related articles - BL Direct - All 6 versions
