SJ Bailey, MA Ravier, GA Rutter - Diabetes, 2007 - Am Diabetes Assoc The mechanism(s) by which glucose regulates glucagon secretion both acutely and in the longer
term remain unclear. Added to isolated mouse islets in the presence of 0.5 mmol/l glucose,
γ-aminobutyric acid (GABA) inhibited glucagon release to a similar extent (46%) as 10 ... Cited by 10 - Related articles - BL Direct - All 7 versions
N Quoix, R Cheng-Xue, Y Guiot, PL Herrera, JC … - FEBS letters, 2007 - Elsevier The control of glucagon secretion by pancreatic α-cells is poorly understood, largely because
of the difficulty to recognize living α-cells. We describe a new mouse model, referred to as
GluCre-ROSA26EYFP (or GYY), allowing easy α-cell identification because of specific ... Cited by 3 - Related articles - All 6 versions
H Zhou, T Zhang, JS Harmon, J Bryan, RP Robertson - Diabetes, 2007 - Am Diabetes Assoc The intraislet insulin hypothesis proposes that the decrement in β-cell insulin secretion during
hypoglycemia provides an activation signal for α-cells to release glucagon. A more recent hypothesis
proposes that zinc atoms suppress glucagon secretion via their ability to open α-cell ATP- ... Cited by 12 - Related articles - BL Direct - All 5 versions
N Tyagi, D Lominadze, W Gillespie, KS … - Clinical Chemical …, 2007 - reference-global.com Background: g-Aminobutyric acid (GABA) is a known inhibitory neurotransmitter in the mammalian
central nervous system, and homocysteine (Hcy) behaves as an antagonist for GABA A
receptor. Although the properties and functions of GABA A receptors are well studied in ... Cited by 2 - Related articles - BL Direct - All 4 versions
YM Leung, I Ahmed, L Sheu, RG Tsushima, NE … - … and Biophysical Research …, 2006 - Elsevier In low or absence of glucose, α-cells generate rhythmic action potentials and secrete
glucagon. α-Cell T-type Ca 2+ channels are believed to be pacemaker channels, which are expected
to open near the resting membrane potential (around −60 mV) to initiate a small ... Cited by 9 - Related articles - All 5 versions
E Vieira, A Salehi, E Gylfe - Diabetologia, 2007 - Springer Abstract Aims/hypothesis The mechanisms by which glucose regu- lates glucagon release are
poorly understood. The present study aimed to clarify the direct effects of glucose on the
glucagon-releasing alpha cells and those effects mediated by paracrine islet factors. ... Cited by 24 - Related articles - BL Direct - All 4 versions
PE MacDonald, YZ De Marinis, R Ramracheya, A … - PLoS Biol, 2007 - biology.plosjournals.org Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis and liver glycogen
breakdown. The mechanism regulating glucagon release is debated, and variously attributed
to neuronal control, paracrine control by neighbouring β cells, or to an intrinsic glucose ... Cited by 26 - Related articles - Cached - All 7 versions
- ►diabetesjournals.org AC Hauge-Evans, AJ King, D Carmignac, CC … - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE— Somatostatin (SST) is secreted by islet δ-cells and by extraislet neuroendocrine
cells. SST receptors have been identified on α- and β-cells, and exogenous SST inhibits insulin
and glucagon secretion, consistent with a role for SST in regulating α- and β-cell function. ... Cited by 5 - Related articles - All 8 versions
YM Leung, I Ahmed, L Sheu, X Gao, M Hara, RG … - Endocrinology, 2006 - Endocrine Soc Glucose regulates pancreatic islet -cell glucagon secretion directly by its metabolism to generate
ATP in -cells, and indirectly via stimulation of paracrine release of ß-cell secretory products, particularly
insulin. How the cellular substrates of these pathways converge in the -cell is not well ... Cited by 21 - Related articles - All 4 versions
- ►endojournals.org YM Leung, I Ahmed, L Sheu, RG Tsushima, NE … - Endocrinology, 2005 - Endocrine Soc We recently reported a transgenic [mouse insulin promoter (MIP)-green fluorescent protein
(GFP)] mouse in which GFP expression is targeted to the pancreatic islet ß-cells to enable convenient
identification of ß-cells as green cells. The GFP-expressing ß-cells of the MIP-GFP mouse ... Cited by 21 - Related articles - BL Direct - All 4 versions
