M Meier, JK Park, D Overheu, T Kirsch, C … - Diabetes, 2007 - Am Diabetes Assoc The protein kinase C (PKC)-β isoform has been implicated to play a pivotal role
in the development of diabetic kidney disease. We tested this hypothesis by
inducing diabetic nephropathy in PKC-β–deficient (PKC-β −/− ) mice. ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►asnjournals.org M Meier, J Menne, JK Park, M Holtz, F Gueler, … - Journal of the American Society of Nephrology, 2007 - Am Soc Nephrol Protein kinase C (PKC), a family of 12 distinct serine-threonine kinases, is an
important intracellular signaling pathway involved in various cellular
functions, such as proliferation, hypertrophy, apoptosis, and adhesion. ... Cited by 7 - Related articles - All 6 versions
RE Gilbert, SA Kim, KR Tuttle, GL Bakris, RD … - Diabetes care, 2007 - Am Diabetes Assoc We obtained urine from participants in a prospective, double-blind,
placebo-controlled study of the effects of ruboxistaurin 32 mg/day in patients
with diabetic nephropathy (11), in which the effect on urinary TGF-β was a ... Cited by 12 - Related articles - BL Direct - All 6 versions
Y Ohshiro, RC Ma, Y Yasuda, J Hiraoka- … - Diabetes, 2006 - Am Diabetes Assoc Diabetes induces the activation of several protein kinase C (PKC) isoforms in
the renal glomeruli. We used PKC-β −/− mice to examine the action of PKC-β
isoforms in diabetes-induced oxidative stress and renal injury at 8 and 24 ... Cited by 38 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org J Soma, K Sato, H Saito, Y Tsuchiya - Nephrology Dialysis Transplantation, 2006 - ERA-EDTA Methods. Among out-patients with diabetes mellitus, we selected patients with
(i) urinary albumin excretion of 30–1000 mg/g creatinine (/gCr) in the first
morning urine, (ii) serum creatinine (SCr) 1.2 mg/dl and no haematuria and ... Cited by 11 - Related articles - BL Direct - All 5 versions
GL Bakris - Clinical Journal of the American Society of Nephrology, 2007 - Am Soc Nephrol Kinases transfer the terminal, "high energy" phosphate group of ATP to a site on
a target protein, thereby activating the protein, which may be an enzyme, cell
membrane receptor, or ion transport channel. The protein kinase C (PKC) ... Cited by 2 - Related articles - BL Direct - All 3 versions
S Tang, V Xiao, L Wei, CI Whiteside, LP … - Proteins: Structure, Function, and Bioinformatics, 2008 - interscience.wiley.com Protein kinase C (PKC) isozymes are an important class of enzymes in cell
signaling and as drug targets. They are involved in specific pathways and have
selectivity towards certain ligands, despite their high sequence ... Cited by 2 - Related articles - BL Direct - All 2 versions
[CITATION] The renal antifibrotic effect of angiotensin-converting enzyme inhibition involve bradykinin …
- ►oxfordjournals.org P Boor, A Konieczny, L Villa, U Kunter, CRC … - Nephrology Dialysis Transplantation, 2007 - ERA-EDTA Results. In vitro, CR002 inhibited the PDGF-D- but not the PDGF-B-induced
proliferation of rat renal fibroblasts. Following the first CR002 injection on
day 17, exposure to therapeutic levels was maintained until day 49. ... Cited by 12 - Related articles - BL Direct - All 5 versions
