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Scholar Results 1 - 10 of about 101 related to Kern: Topical administration of nepafenac inhibits diabetes-induced retinal microvascular.... (0.16 sec) 

Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease …

- diabetesjournals.org
TS Kern, CM Miller, Y Du, L Zheng, S Mohr, … - Diabetes, 2007 - Am Diabetes Assoc
Pharmacologic treatment of diabetic retinopathy via eyedrops could have
advantages but has not been successful to date. We explored the effect of
topical Nepafenac, an anti-inflammatory drug known to reach the retina when ...
Cited by 35 - Related articles - BL Direct - All 4 versions

Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy

- diabetesjournals.org
L Zheng, SJ Howell, DA Hatala, K Huang, TS … - Diabetes, 2007 - Am Diabetes Assoc
It has been previously reported that aspirin inhibited the development of
diabetic retinopathy in diabetic animals, raising the possibility that
anti-inflammatory drugs may have beneficial effects on diabetic ...
Cited by 42 - Related articles - BL Direct - All 12 versions

Inhibition of caspase-1/interleukin-1β signaling prevents degeneration of retinal capillaries …

- shouxi.net
JA Vincent, S Mohr - Diabetes, 2007 - Am Diabetes Assoc
The proinflammatory cytokine, interleukin (IL)-1β, is known to induce vascular
dysfunction and cell death. We investigated the role of IL-1β and caspase-1
(the enzyme that produces it) in diabetes-induced degeneration of retinal ...
Cited by 19 - Related articles - BL Direct - All 5 versions

Aspirin at Low-Intermediate Concentrations Protects Retinal Vessels in Experimental …

- shouxi.net
W Sun, C Gerhardinger, Z Dagher, T Hoehn, … - Diabetes, 2005 - Am Diabetes Assoc
The prevention of diabetic retinopathy requires drugs that leverage the benefits
of glycemic control without adding the burden of side effects. Aspirin at
dosages of 1–1.5 g/day has prevented manifestations of diabetic retinal ...
Cited by 24 - Related articles - BL Direct - All 6 versions

Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes

- iovs.org
L Zheng, B Gong, DA Hatala, TS Kern - Investigative ophthalmology & visual science, 2007 - ARVO
METHODS. I/R injury to the retinas was induced in Lewis rats and C57BL/6J mice
by elevating intraocular pressure (IOP), and reperfusion was established
immediately afterward. Some rats were pretreated with aminoguanidine (AMG, ...
Cited by 21 - Related articles - BL Direct - All 3 versions

Inflammation-mediated retinal edema in the rabbit is inhibited by topical nepafenac


MA Kapin, JM Yanni, MT Brady, TJ … - Inflammation, 2003 - Springer
Abstract—The purpose of this study was to evaluate the ability of the
nonsteroidal anti-inflammatory drug nepafenac to prevent development of
mitogen-induced pan-retinal edema following topical oc- ular application in ...
Cited by 29 - Related articles - BL Direct - All 5 versions

Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice …


L Zheng, Y Du, C Miller, RA Gubitosi-Klug, TS … - Diabetologia, 2007 - Springer
Page 1. ARTICLE Critical role of inducible nitric oxide synthase in degeneration
of retinal capillaries in mice with streptozotocin-induced diabetes ...
Cited by 29 - Related articles - BL Direct - All 7 versions

Retinal glial cell immunoreactivity and neuronal cell changes in rats with STZ-induced …


E Agardh, A Bruun, CD Agardh - Current Eye Research, 2001 - informahealthcare.com
Methods. Streptozocin (STZ)-induced diabetic male Wistar rats and age-matched
control rats were fed a normal diet, addition of AG in the drinking water
(0.5g/l for diabetic and 1.0g/l for control rats) or PB in the pellets (1% ...
Cited by 18 - Related articles - BL Direct - All 7 versions

Dog and rat models of diabetic retinopathy


TS KERN, R KOWLURU, RL ENGERMAN - Lessons from animal diabetes VI: 75th anniversary of …, 1996 - books.google.com
Dog and rat models of diabetic retinopathy TIMOTHY S. KERN, RENU KOWLURU, AND
RONALD L. ENGERMAN Department of Ophthalmology and Visual Science, University of
Wisconsin-Madison, Madison, Wisconsin 53706, USA. Key words: dog, rat, ...
Cited by 8 - Related articles

Non-uniform distribution of lesions and biochemical abnormalities within the retina of …


J Tang, S Mohr, YP Du, TS Kern - Current Eye Research, 2003 - informahealthcare.com
Objective. Microaneurysms, acellular capillaries, pericyte ghosts, and
thickening of retinal capillary basement mem- brane are characteristic of
diabetic retinopathy, and are believed to be sequelae of excessive blood ...
Cited by 11 - Related articles - BL Direct - All 6 versions


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