- ►diabetesjournals.org I Nieto-Vazquez, S Fernández-Veledo, C de Alvaro, … - Diabetes, 2007 - Am Diabetes Assoc Protein–tyrosine phosphatase (PTP)1B is a negative regulator of insulin signaling and a therapeutic
target for type 2 diabetes. In this study, we have assessed the role of PTP1B in the insulin sensitivity
of skeletal muscle under physiological and insulin-resistant conditions. Immortalized ... Cited by 21 - Related articles - BL Direct - All 6 versions
S Fernandez-Veledo, I Nieto-Vazquez, CM Rondinone, … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis The nuclear receptors, including nuclear receptor subfamily 1, group
H, member 3 (NR1HR, also known as liver X receptor [LXR]), are sensors of cholesterol metabolism
and lipid biosynthesis that have recently been proposed as insulin sensitisers. TNFα has ... Cited by 17 - Related articles - All 4 versions
Y Wu, JP Ouyang, K Wu, SS Wang, CY … - British journal of …, 2005 - pubmedcentral.nih.gov Protein tyrosine phosphatase 1B (PTP1B) acts as a physiological negative regulator of insulin
signaling by dephosphorylating the activated insulin receptor (IR). Here we examine the role
of PTP1B in the insulin-sensitizing action of rosiglitazone (RSG) in skeletal muscle and liver. Cited by 13 - Related articles - BL Direct - All 4 versions
- ►nih.gov M Delibegovic, KK Bence, N Mody, EG Hong, … - Molecular and cellular …, 2007 - Am Soc Microbiol Obesity and type 2 diabetes are characterized by insulin resistance. Mice lacking the
protein-tyrosine phosphatase PTP1B in all tissues are hypersensitive to insulin but also have
diminished fat stores. Because adiposity affects insulin sensitivity, the extent to which ... Cited by 15 - Related articles - BL Direct - All 11 versions
B Xue, YB Kim, A Lee, E Toschi, S Bonner-Weir, CR … - Journal of Biological …, 2007 - ASBMB Mice heterozygous for insulin receptor (IR) and IR substrate (IRS)-1 deficiency provide a model
of polygenic type 2 diabetes in which early-onset, genetically programmed insulin resistance
leads to diabetes. Protein-tyrosine phosphatase 1B (PTP1B) dephosphorylates tyrosine ... Cited by 13 - Related articles - All 7 versions
- ►diabetesjournals.org I Nieto-Vazquez, S Fernández-Veledo, C de Alvaro, M … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—IL-6 per se increased glucose uptake by activating serine/threonine protein kinase
11 (LKB1)/AMP-activated protein kinase/protein kinase B substrate of 160 kDa (AS160)
pathway. A dual effect on insulin action was observed when myotubes and mice were ... Cited by 8 - Related articles - All 5 versions
- ►animal-science.org M Lorenzo, S Fernandez-Veledo, R Vila- … - Journal of animal …, 2008 - animal-science.org Insulin resistance is an important contributor to the pathogenesis of type 2 diabetes, and obesity
is a risk factor for its development, in part because adipose tissue secretes proteins, called
adipokines, that may influence insulin sensitivity. Among these molecules, tumor necrosis ... Cited by 9 - Related articles - All 5 versions
JM Zabolotny, FG Haj, YB Kim, HJ Kim, GI Shulman … - Journal of Biological …, 2004 - ASBMB Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte
antigen-related phosphatase (LAR) as negative regulators of insulin signaling. The expression
and/or activity of PTP1B and LAR are increased in muscle of insulin-resistant rodents and ... Cited by 55 - Related articles - BL Direct - All 8 versions
- ►endojournals.org S Fernandez-Veledo, I Nieto-Vazquez, J de … - Journal of Clinical …, 2008 - Endocrine Soc Results: Adipocytes differentiated for 14 d gain insulin sensitivity on glucose uptake and inhibition
of lipolysis, but prolonged cultures develop an insulin-resistant state characterized by an increase
in phosphatase and tensin homolog-deleted on chromosome 10 expression and defects ... Cited by 8 - Related articles - All 4 versions
S Fernández-Veledo, R Hernandez, T … - … of physiology and …, 2006 - informahealthcare.com Tumour necrosis factor (TNF)-α impaired insulin induction on GLUT4 mRNA in foetal brown
adipocytes, as demonstrated by quantitative RT-PCR and Northern blot. We have explored the
hypothesis that some effects of TNF-α could be mediated by the generation of ceramide, ... Cited by 16 - Related articles - BL Direct - All 7 versions
