FSL Thong, PJ Bilan, A Klip - Diabetes, 2007 - Am Diabetes Assoc Insulin-dependent phosphorylation of Akt target AS160 is required for GLUT4 translocation. Insulin
and platelet-derived growth factor (PDGF) (Akt activators) or activation of conventional/novel
(c/n) protein kinase C (PKC) and 5′ AMP-activated protein kinase (AMPK) all promote a ... Cited by 43 - Related articles - BL Direct - All 5 versions
G Ramm, M Larance, M Guilhaus, DE James - Journal of Biological Chemistry, 2006 - ASBMB Translocation of the insulin-regulated glucose transporter GLUT4 to the cell surface is dependent
on the phosphatidylinositol 3-kinase/Akt pathway. The RabGAP (Rab GTPase-activating
protein) AS160 (Akt substrate of 160 kDa) is a direct substrate of Akt and plays an ... Cited by 43 - Related articles - All 6 versions
S Ishikura, PJ Bilan, A Klip - Biochemical and biophysical research …, 2007 - Elsevier Insulin causes translocation of glucose transporter GLUT4 to the membrane of muscle and fat
cells, a process requiring Akt activation. The Rab GTPase-activating protein (Rab-GAP) AS160
is inhibited upon phosphorylation by insulin-activated Akt, thereby allowing GLUT4 ... Cited by 37 - Related articles - All 4 versions
KM Geraghty, S Chen, JE Harthill, AF … - The Biochemical …, 2007 - pubmedcentral.nih.gov AS160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose transporter 4)
translocation, but is widely expressed in insulin-insensitive tissues lacking GLUT4. Having isolated
AS160 by 14-3-3-affinity chromatography, we found that binding of AS160 to 14-3-3 ... Cited by 28 - Related articles - BL Direct - All 6 versions
- ►jbc.org JA Chavez, WG Roach, SR Keller, WS Lane, GE … - Journal of Biological …, 2008 - ASBMB Insulin increases glucose transport by stimulating the trafficking of intracellular GLUT4 to the
cell surface, a process known as GLUT4 translocation. A key protein in signaling this process
is AS160, a Rab GTPase-activating protein (GAP) whose activity appears to be ... Cited by 23 - Related articles - All 5 versions
- ►endojournals.org GR Peck, S Ye, V Pham, RN Fernando, SL … - Molecular …, 2006 - Endocrine Soc Insulin-regulated aminopeptidase (IRAP), a marker of glucose transporter 4 (GLUT4) storage
vesicles (GSVs), is the only protein known to traffic with GLUT4. In the basal state, GSVs are
sequestered from the constitutively recycling endosomal system to an insulin-responsive, ... Cited by 34 - Related articles - BL Direct - All 3 versions
- ►cell.com H Sano, L Eguez, MN Teruel, M Fukuda, TD Chuang, … - Cell Metabolism, 2007 - Elsevier GLUT4 trafficking to the plasma membrane of muscle and fat cells is regulated by insulin. An
important component of insulin-regulated GLUT4 distribution is the Akt substrate AS160 rab
GTPase-activating protein. Here we show that Rab10 functions as a downstream target of ... Cited by 44 - Related articles - All 7 versions
WG Roach, JA Chavez, CP Mîinea, GE … - Biochemical …, 2007 - pubmedcentral.nih.gov Insulin stimulation of the trafficking of the glucose transporter GLUT4 to the plasma membrane
is controlled in part by the phosphorylation of the Rab GAP (GTPase-activating protein) AS160
(also known as Tbc1d4). Considerable evidence indicates that the phosphorylation of this ... Cited by 31 - Related articles - BL Direct - All 6 versions
EB Taylor, D An, HF Kramer, H Yu, NL Fujii, KSC … - Journal of Biological …, 2008 - ASBMB The Akt substrate of 160 kDa (AS160) is phosphorylated on Akt substrate (PAS) motifs in response
to insulin and contraction in skeletal muscle, regulating glucose uptake. Here we discovered
a dissociation between AS160 protein expression and apparent AS160 PAS ... Cited by 34 - Related articles - All 6 versions
- ►cell.com L Bai, Y Wang, J Fan, Y Chen, W Ji, A Qu, P Xu, DE … - Cell Metabolism, 2007 - Elsevier Insulin-stimulated GLUT4 translocation is central to glucose homeostasis. Functional assays
to distinguish individual steps in the GLUT4 translocation process are lacking, thus limiting progress
toward elucidation of the underlying molecular mechanism. Here we have developed a ... Cited by 48 - Related articles - All 12 versions
