KG Park, KM Lee, HY Seo, JH Suh, HS Kim, L Wang, … - Diabetes, 2007 - Am Diabetes Assoc Prolonged elevations of glucose concentration have deleterious effects on β-cell function. One
of the hallmarks of such glucotoxicity is a reduction in insulin gene expression, resulting from
decreased insulin promoter activity. Small heterodimer partner (SHP; NR0B2) is an ... Cited by 18 - Related articles - BL Direct - All 7 versions
YH Hsieh, IJ Su, HY Lei, MD Lai, WW Chang, W … - … and Biophysical Research …, 2007 - Elsevier Accumulated misfolded proteins in endoplasmic reticulum (ER) activate ER stress signaling
pathways. Here we identified the ER factors that generate ROS molecules. After mouse NIH3T3
cells were treated with either tunicamycin or thapsigargin, oxidative stress was induced. ... Cited by 11 - Related articles - All 6 versions
- ►ulb.ac.be [PDF] P Pirot, N Naamane, F Libert, NE Magnusson, TF … - Diabetologia, 2007 - Springer Page 1. ARTICLE Global profiling of genes modified by endoplasmic reticulum stress in
pancreatic beta cells reveals the early degradation of insulin mRNAs P. Pirot & N. Naamane
& F. Libert & NE Magnusson & TF Ørntoft & AK Cardozo & DL Eizirik ... Cited by 26 - Related articles - BL Direct - All 6 versions
[CITATION] Principles and practice of endocrinology and metabolism
- ►endojournals.org JY Kim, K Chu, HJ Kim, HA Seong, KC Park, S … - Molecular …, 2004 - Endocrine Soc Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor that lacks a
conventional DNA binding domain (DBD) and represses the transcriptional activity of various
nuclear receptors. In this study, we examined the novel cross talk between SHP and ... Cited by 32 - Related articles - BL Direct - All 4 versions
- ►nih.gov AJ Ball, AE Abrahamsson, B Tyrberg, P Itkin-Ansari, … - … and biophysical research …, 2007 - Elsevier To examine the mechanism by which growth-stimulated pancreatic β-cells dedifferentiate, somatic
cell fusions were performed between MIN6, a highly differentiated mouse insulinoma, and
βlox5, a cell line derived from human β-cells which progressively dedifferentiated in ... Cited by 3 - Related articles - All 8 versions
T Namba, T Ishihara, K Tanaka, T Hoshino, T … - … and Biophysical Research …, 2007 - Elsevier Previous studies have shown that modification of activating transcription factor 6 (ATF6) protein
is important for the endoplasmic reticulum (ER) stress response; ER stressors stimulate the degradation
of ATF6 by Site-1 protease (S1P) and Site-2 protease (S2P) into p50-ATF6, which acts as ... Cited by 7 - Related articles - All 5 versions
- ►jbc.org MH Oosterveer, TH van Dijk, A Grefhorst, VW Bloks, … - Journal of Biological …, 2008 - ASBMB Besides its well established role in control of cellular cholesterol homeostasis, the liver X receptor
(LXR) has been implicated in the regulation of hepatic gluconeogenesis. We investigated the
role of the major hepatic LXR isoform in hepatic glucose metabolism during the ... Cited by 6 - Related articles - All 6 versions
S Lu, WP Wang, XF Wang, ZM Zheng, P Chen, KT … - World J …, 2005 - wjg.wjgnet.com RESULTS: Exogenous PDX-1 transgene was proved to express effectively in HepG2 cell at both
mRNA and protein levels. The expression of endogenous insulin and some b cell-specific differentiation
markers and transcription factors were not induced in PDX-1 + HepG2 cells. When ... Cited by 7 - Related articles - Cached - All 6 versions
- ►endojournals.org HY Seo, YD Kim, KM Lee, AK Min, MK Kim, HS Kim, KC … - Endocrinology, 2008 - Endocrine Soc The highly developed endoplasmic reticulum (ER) structure of pancreatic β-cells is a key factor
in β-cell function. Here we examined whether ER stress-induced activation of activating transcription
factor (ATF)-6 impairs insulin gene expression via up-regulation of the orphan nuclear ... Cited by 10 - Related articles - All 4 versions
