- ►diabetesjournals.org R Lehmann, RA Zuellig, P Kugelmeier, PB Baenninger, … - Diabetes, 2007 - Am Diabetes Assoc Many factors influence the outcome of islet transplantation. As islets in the early posttransplant
setting are supplied with oxygen by diffusion only and are in a hypoxic state in the portal
system, we tested whether small human islets are superior to large islets both in vitro and ... Cited by 22 - Related articles - BL Direct - All 13 versions
- ►physiology.org RR MacGregor, SJ Williams, PY Tong, K … - American Journal of …, 2006 - Am Physiological Soc Barriers to the use of islet transplantation as a practical treatment for diabetes include the limited
number of available donor pancreata. This project was designed to determine whether the size
of the islet could influence the success rate of islet transplantations in rats. Islets from ... Cited by 19 - Related articles - BL Direct - All 3 versions
G Cavallari, RA Zuellig, R Lehmann, M Weber, W … - Transplantation …, 2007 - Elsevier Rejection and hypoxia are the main factors that limit islet engraftment in the recipient liver in
the immediate posttransplant period. Recently authors have reported a negative relationship
of graft function and islet size, concluding that small islets are superior to large islets. ... Cited by 3 - Related articles - All 17 versions
C Kampf, G Mattsson, PO Carlsson - Cell Transplantation, 2006 - ingentaconnect.com For their survival and optimal function, pancreatic islets depend posttransplantation on a rapid
and adequate revascularization. Native islets display a marked size-dependent heterogeneity
in both angioarchitecture and degree of blood perfusion. This study evaluated whether ... Cited by 6 - Related articles - BL Direct - All 2 versions
[CITATION] Long-term survival of cynomolgus monkey islets implanted in an omental pouch …
MA Mach, J Schlosser, M Weiland, PJ Feilen, M Ringel, … - Acta Diabetologica, 2003 - Springer Abstract Large amounts and excellent viabilities of pancre- atic islets are prerequisites for recent
advances in islet trans- plantation. Cryopreservation has been shown to enlarge transplanted
cell mass, but has been accompanied by reduced viability. In this study rat pancreatic ... Cited by 8 - Related articles - BL Direct - All 4 versions
F Bertuzzi, C Ricordi - Diabetes Care, 2007 - Am Diabetes Assoc Graft function prediction is a work in progress. Initially, the best parameters representative of
engrafted islet mass in recipients should be defined. Fasting C-peptide and exogenous insulin
requirements are commonly used, although other methods for a more complete ... Cited by 19 - Related articles - All 7 versions
HC Kang, YH Bae - Diabetes Technology & Therapeutics, 2009 - liebertonline.com Abstract Background: In vitro genetic modification has been regarded as one option to improve
the viability and func- tionality of pancreatic islets when used for transplantation in patients with
diabetes, either as naked islets or in a type of bioartificial pancreas. In this approach, ... Cited by 1 - Related articles - All 3 versions
O Korsgren, T Lundgren, M Felldin, A Foss, B Isaksson, … - Diabetologia, 2008 - Springer Page 1. FOR DEBATE Optimising islet engraftment is critical for successful clinical islet
transplantation O. Korsgren & T. Lundgren & M. Felldin & A. Foss & B. Isaksson & J. Permert &
NH Persson & E. Rafael & M. Rydén & K. Salmela & A. Tibell & G. Tufveson & B. Nilsson ... Cited by 15 - Related articles - BL Direct - All 2 versions
- ►pnas.org B Keymeulen, P Gillard, C Mathieu, B … - Proceedings of the …, 2006 - National Acad Sciences Islet grafts can induce insulin independence in type 1 diabetic patients, but their function is variable
with only 10% insulin indepence after 5 years. We investigated whether cultured grafts with defined
β cell number help standardize metabolic outcome. Nonuremic C-peptide-negative ... Cited by 27 - Related articles - BL Direct - All 10 versions
