- ►diabetesjournals.org T Brusko, C Wasserfall, K McGrail, R Schatz, … - Diabetes, 2007 - Am Diabetes Assoc Regulatory T-cells (Tregs) play a critical role in maintaining dominant
peripheral tolerance. Previous characterizations of Tregs in type 1 diabetes
have used antibodies against CD4 and α-chain of the interleukin-2 receptor ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org TM Brusko, CH Wasserfall, MJ Clare-Salzler, … - Diabetes, 2005 - Am Diabetes Assoc CD4 + CD25 + T-cells appear to play a crucial role in regulating the immune
response. Therefore, we evaluated the peripheral blood frequency and function of
CD4 + CD25 + T-cells in 70 type 1 diabetic patients and 37 healthy ... Cited by 108 - Related articles - All 5 versions
AL Putnam, F Vendrame, F Dotta, PA Gottlieb - Journal of Autoimmunity, 2005 - Elsevier In mouse models, CD4 + CD25 + T cells are involved in maintenance of peripheral
tolerance. In humans, a subset of CD4 + CD25 + T cells expressing high levels of
CD25 (CD4 + CD25 high ) with characteristics identical to murine CD4 + CD25 ... Cited by 75 - Related articles - All 3 versions
- ►diabetesjournals.org M Tritt, E Sgouroudis, E d'Hennezel, A … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—We show that the cellular frequency of Foxp3 + nT reg cells in primary
and secondary lymphoid tissues is stable and does not decline relative to type 1
diabetes–resistant mice. We show that thymic and peripheral CD4 + CD25 + ... Cited by 33 - Related articles - BL Direct - All 5 versions
TIM TREE, BO ROEP, M PEAKMAN - Annals of the New York Academy of Sciences, 2006 - cat.inist.fr Type 1 diabetes mellitus(T 1 DM) is characterized by a loss of self-tolerance to
islet antigens. In health, immunological tolerance is maintained by multiple
central and peripheral mechanisms including the action of a specialized set ... Cited by 20 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org A Schneider, M Rieck, S Sanda, C Pihoker, … - The Journal of Immunology, 2008 - Am Assoc Immnol Defects in immune regulation have been implicated in the pathogenesis of
diabetes in mouse and in man. In vitro assays using autologous regulatory (Treg)
and responder effector (Teff) T cells have shown that suppression is ... Cited by 9 - Related articles - All 2 versions
S Lindley, CM Dayan, A Bishop, BO Roep, M … - Diabetes, 2005 - Am Diabetes Assoc Type 1 diabetes is a T-cell–mediated disease that is associated with loss of
immunological tolerance to self-antigens. The mechanisms involved in maintenance
of peripheral tolerance include a specialized subset of regulatory T-cells ... Cited by 290 - Related articles - All 5 versions
- ►nih.gov Q Tang, JY Adams, C Penaranda, K Melli, E … - Immunity, 2008 - Elsevier The dynamics of CD4 + effector T cells (Teff cells) and CD4 + Foxp3 + regulatory
T cells (Treg cells) during diabetes progression in nonobese diabetic mice was
investigated to determine whether an imbalance of Treg cells and Teff cells ... Cited by 53 - Related articles - All 7 versions
P Zavattari, E Deidda, M Pitzalis, B Zoa, L … - Diabetes, 2004 - Am Diabetes Assoc Mutations of the forkhead/winged helix transcription factor FOXP3 gene on
chromosome Xp11.23 cause a rare recessive monogenic disorder called IPEX (immune
dysregulation, polyendocrinopathy, including type 1 diabetes, enteropathy, ... Cited by 27 - Related articles - BL Direct - All 5 versions
RJ Mellanby, D Thomas, JM Phillips, A Cooke - Immunology, 2007 - pubmedcentral.nih.gov The role of regulatory T cells (Tregs) in maintaining self tolerance has been
intensively researched and there is a growing consensus that a decline in Treg
function is an important step towards the development of autoimmune ... Cited by 27 - Related articles - BL Direct - All 7 versions
