- ►diabetesjournals.org R Mallone, E Martinuzzi, P Blancou, G Novelli, G … - Diabetes, 2007 - Am Diabetes Assoc Despite the understanding that type 1 diabetes pathogenesis is mediated by T-cells, detection
of these rare lymphocytes remains largely elusive. Suitable T-cell assays are highly needed,
since they could offer preclinical diagnoses and immune surrogate end points for clinical ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org Q Ouyang, NE Standifer, H Qin, P Gottlieb, CB … - Diabetes, 2006 - Am Diabetes Assoc Type 1 diabetes results from the autoimmune destruction of insulin-producing pancreatic β-cells
by cytotoxic T-lymphocytes (CTLs). In humans, few β-cell epitopes have been reported, thereby
limiting the study of β-cell–specific CTLs in type 1 diabetes. To identify additional ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org NE Standifer, Q Ouyang, C Panagiotopoulos, CB … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-lymphocytes (CTLs) are considered to be essential for β-cell destruction in type 1
diabetes. However, few islet-associated peptides have been demonstrated to activate autoreactive
CTLs from type 1 diabetic subjects. In an effort to identify novel epitopes, we used matrix- ... Cited by 28 - Related articles - BL Direct - All 5 versions
A Toma, S Haddouk, JP Briand, L … - Proceedings of the …, 2005 - National Acad Sciences Proinsulin is a key autoantigen in type 1 diabetes. Evidence in the mouse has underscored the
importance of the insulin B chain region in autoimmunity to pancreatic beta cells. In man, a majority
of proteasome cleavage sites are predicted by proteasome cleavage algorithms within ... Cited by 56 - Related articles - BL Direct - All 8 versions
- ►jimmunol.org T Takaki, MP Marron, CE Mathews, ST … - The Journal of …, 2006 - Am Assoc Immnol In both humans and NOD mice, particular MHC genes are primary contributors to development
of the autoreactive CD4 + and CD8 + T cell responses against pancreatic cells that cause type
1 diabetes (T1D). Association studies have suggested, but not proved, that the ... Cited by 33 - Related articles - BL Direct - All 5 versions
Y Hassainya, F Garcia-Pons, R Kratzer, V Lindo, F … - Diabetes, 2005 - Am Diabetes Assoc Type 1 diabetes is thought to result from the destruction of β-cells by autoantigen-specific
T-cells. Observations in the NOD mouse model suggest that CD8 + cytotoxic T-cells play an essential
role in both the initial triggering of insulitis and its destructive phase. However, little is ... Cited by 43 - Related articles - All 6 versions
RMEMP Blancou, G Novelli, GAM Dolz, G Bruno, L … - 糖尿病学杂志, 2007 - journal.shouxi.net 【摘要】 Despite the understanding that type 1 diabetes pathogenesis is mediated by T-cells, detection
of these rare lymphocytes remains largely elusive. Suitable T-cell assays are highly needed,
since they could offer preclinical diagnoses and immune surrogate end points for clinical ... Related articles - Cached
- ►diabetesjournals.org I Jarchum, JC Baker, T Yamada, T Takaki, MP Marron, … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—We found that HLA-A*0201-restricted T-cells isolated from the islets of the transgenic
mice were specific for Ins1 L3–11, Ins1 B5–14, and Ins1/2 A2–10. Insulin-reactive T-cells were
present in the islets of mice as young as 5 weeks of age, suggesting an important function ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org P Blancou, R Mallone, E Martinuzzi, S … - The Journal of …, 2007 - Am Assoc Immnol Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic cells. CD8 + T cells
have recently been assigned a major role in cell injury. Consequently, the identification of autoreactive
CD8 + T cells in humans remains essential for development of therapeutic strategies and ... Cited by 10 - Related articles - All 6 versions
- ►pnas.org GGM Pinkse, OHM Tysma, CAM Bergen, … - Proceedings of the …, 2005 - National Acad Sciences Type 1 diabetes is a T cell-mediated autoimmune disease, and insulin is an important target
of the autoimmune response associated with β cell destruction. The mechanism of destruction
is still unknown. Here, we provide evidence for CD8 T cell autoreactivity associated with ... Cited by 88 - Related articles - BL Direct - All 10 versions
