T Thum, D Fraccarollo, M Schultheiss, S Froese, P … - Diabetes, 2007 - Am Diabetes Assoc Uncoupling of the endothelial nitric oxide synthase (eNOS) resulting in superoxide anion (O
2 − ) formation instead of nitric oxide (NO) causes diabetic endothelial dysfunction. eNOS regulates
mobilization and function of endothelial progenitor cells (EPCs), key regulators of ... Cited by 72 - Related articles - BL Direct - All 10 versions
- ►oxfordjournals.org T Thum, D Fraccarollo, P Galuppo, D … - Cardiovascular …, 2006 - cardiovascres.oxfordjournals.org Methods and results We studied the effects of ACE inhibition or statin treatment on EPC levels
and on bone marrow molecular pathways involved in EPC mobilization after MI in rats. Three
days post-infarction, acetylated LDL (acLDL) + /Ulex europeus-1 (UEA-1) + /VEGF ... Cited by 38 - Related articles - All 7 versions
T Thum, S Hoeber, S Froese, I Klink, DO … - Circulation …, 2007 - Am Heart Assoc Kluwer Health, 351 West Camden Street, Baltimore, MD 21202-2436. Phone:
410-528-4050. Permissions: Permissions & Rights Desk, Lippincott Williams & Wilkins, a division
of Wolters ... Age-Dependent Impairment of Endothelial Progenitor Cells Cited by 67 - Related articles - All 7 versions
- ►ahajournals.org SA Sorrentino, FH Bahlmann, C Besler, M Muller, S … - Circulation, 2007 - Am Heart Assoc Methods and Results— In vivo reendothelialization capacity of EPCs from diabetic patients
(n=30) and healthy subjects (n=10) was examined in a nude mouse carotid injury model. Superoxide
and NO production of EPCs was determined by electron spin resonance spectroscopy. ... Cited by 62 - Related articles - All 10 versions
- ►ahajournals.org G Galasso, S Schiekofer, K Sato, R Shibata, DE … - Circulation …, 2006 - Am Heart Assoc Several vascular disease are characterized by elevated levels of reactive oxygen species
(ROS). Vascular endothelium is protected from oxidant stress by expressing enzymes such as
glutathione peroxidase type 1 (GPx-1). In this study, we investigated the effect of vascular ... Cited by 59 - Related articles - All 10 versions
- ►ahajournals.org M Ii, H Takenaka, J Asai, K Ibusuki, Y Mizukami, K … - Circulation …, 2006 - Am Heart Assoc Delayed reendothelialization contributes to restenosis after angioplasty and stenting in
diabetes. Prior data have shown that bone marrow (BM)-derived endothelial progenitor cells
(EPCs) contribute to endothelial recovery after arterial injury. We investigated the ... Cited by 55 - Related articles - All 9 versions
YH Chen, SJ Lin, FY Lin, TC Wu, CR Tsao, PH Huang, … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Chronic incubation with high glucose but not mannitol (osmotic control) dose-dependently
reduced the number and proliferation of early and late EPCs, respectively. High glucose enhanced
EPC senescence and impaired the migration and tube formation of late EPCs. High ... Cited by 41 - Related articles - BL Direct - All 8 versions
T Thum - eprints.imperial.ac.uk Page 1. 1 Imperial College London National Heart & Lung Institute ENDOTHELIAL
PROGENITOR CELL DYSFUNCTION – MECHANISMS AND THERAPEUTIC
APPROACHES PhD thesis by Thomas Thum, MD 2008 Page 2. 2 ... Related articles - View as HTML - All 8 versions
- ►ahajournals.org T Thum, D Fraccarollo, S Thum, M Schultheiss … - … , and vascular biology, 2007 - Am Heart Assoc Methods and Results— We compared the effects of 2 different nitrates on circulating EPC numbers
and function. Treatment of rats with pentaerythritol-trinitrate (PETriN) or isosorbide dinitrate
(ISDN) increased circulating EPC levels. EPC from ISDN- but not PETriN-treated animals ... Cited by 24 - Related articles - All 9 versions
- ►onlinejacc.org T Thum, D Tsikas, S Stein, M Schultheiss, M … - Journal of the American …, 2005 - Elsevier Endothelial progenitor cells play a pivotal role in regeneration of injured endothelium, thereby
limiting the formation of atherosclerotic lesions. Reduced numbers of EPCs may affect progression
of coronary artery disease. Regulation of EPC mobilization and function is mediated in ... Cited by 112 - Related articles - BL Direct - All 14 versions
