A Lteif, P Vaishnava, AD Baron, KJ Mather - Diabetes, 2007 - Am Diabetes Assoc The normal action of insulin to vasodilate and redistribute blood flow in support of skeletal muscle
metabolism is impaired in insulin-resistant states. Increased endogenous endothelin contributes
to endothelial dysfunction in obesity and diabetes. Here, we test the hypothesis that ... Cited by 24 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org G Ahlborg, A Shemyakin, F Böhm, A Gonon, J … - Diabetes care, 2007 - Am Diabetes Assoc RESULTS—Total-body glucose uptake (M) differed between the clamp protocols with the highest
value in the BQ123+BQ788 clamp (P < 0.05). The M value corrected by insulin was higher in
the BQ123+BQ788 than in the control clamp (P < 0.01) or the BQ123 clamp (P < 0.05). ... Cited by 11 - Related articles - BL Direct - All 7 versions
- ►pubget.com [PDF] RM Ross, CM Kolka, S Rattigan, MG Clark - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Plasma levels of endothelin-1 are fre- quently elevated in patients with
hypertension, obesity and type 2 diabetes. We hypothesise that this vasoconstric- tor may prevent
full perfusion of muscle, thereby limiting delivery of insulin and glucose and contributing ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►physiology.org G Ahlborg, J Lindstrom - Journal of Applied Physiology, 2002 - Am Physiological Soc Cardiovascular diseases are characterized by insulin resistance and elevated endothelin
(ET)-1 levels. Furthermore, ET-1 induces insulin resistance. To elucidate this mechanism, six
healthy subjects were studied during a hyperinsulinemic euglycemic clamp during ... Cited by 14 - Related articles - BL Direct - All 6 versions
SA Said, ESM Ammar, GM Suddek - Pharmacological Research, 2005 - Elsevier Elevated plasma ET-1 levels have been reported in several conditions such as stress and
diabetes. ET-1 is found to cause insulin resistance and to stimulate liver glycogenolysis. The
question arises whether ET-1 has a role in the metabolic changes occurring in such ... Cited by 6 - Related articles - All 3 versions
N Berthiaume, JL Wessale, TJ Opgenorth, BA Zinker - Metabolism, 2005 - Elsevier Atrasentan, an endothelin antagonist, would have beneficial effects on metabolic responses
in a model of insulin resistance. Zucker lean or fatty rats were maintained either on regular (lean
and fatty control, n = 12) or atrasentan-treated water (5 mg/kg/d, fatty atrasentan, n = 13) ... Cited by 7 - Related articles - All 12 versions
W Bakker, P Sipkema, CDA Stehouwer, EH Serne, YM … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—In the absence of PKC activation, insulin did not alter arterial diameter, which was
caused by a balance of nitric oxide–dependent vasodilator and endothelin-dependent vasoconstrictor
effects. Using three-dimensional microscopy and Western blotting of muscle resistance ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►ebmonline.org S Maeda, S Jesmin, M Iemitsu, T Otsuki, T Matsuo, K … - Experimental Biology and …, 2006 - SEBM Obesity is associated with endothelial dysfunction that may contribute to the development of
diabetes, hypertension, and atherosclerosis. Endothelin-1 (ET-1), which is produced mostly by
vascular endothelial cells, has potent vasoconstrictor and proliferative activity in vascular ... Cited by 10 - Related articles - BL Direct - All 3 versions
B Balsiger, A Rickenbacher, PJ Boden, E … - Clinical …, 2002 - cs.portlandpress.com Secondary complications of diabetes mellitus often involve gastrointestinal dysfunction. In the
experimental Goto Kakizaki rat, a model of Type II diabetes, hyperglycaemia and reduced glucose
clearance is associated with elevated plasma endothelin (ET)-1 levels and selective ... Cited by 13 - Related articles - Cached - BL Direct - All 13 versions
AA Lteif, AD Fulford, RV Considine, I … - American Journal of …, 2008 - Am Physiological Soc Endogenous endothelin action is augmented in human obesity and type 2 diabetes and contributes
to endothelial dysfunction and impairs insulin-mediated vasodilation in humans. We hypothesized
that insulin resistance-associated hyperinsulinemia could preferentially drive endothelin- ... Cited by 2 - Related articles - All 3 versions
