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Scholar Results 1 - 10 of about 101 related to Speier: Cx36-mediated coupling reduces β-cell heterogeneity, confines the stimulating glucose.... (0.12 sec) 

Cx36-mediated coupling reduces β-cell heterogeneity, confines the stimulating …


S Speier, A Gjinovci, A Charollais, P Meda, M Rupnik - Diabetes, 2007 - Am Diabetes Assoc
We studied the effect of gap junctional coupling on the excitability of β-cells in slices of
pancreas, which provide a normal environment for islet cells. The electrophysiological properties
of β-cells from mice (C57Bl/6 background) lacking the gap junction protein connexin36 ( ...
Cited by 15 - Related articles - BL Direct - All 5 versions

Glucose represses connexin36 in insulin-secreting cells

- biologists.org
F Allagnat, D Martin, DF Condorelli, G Waeber, … - Journal of cell …, 2005 - jcs.biologists.org
The gap-junction protein connexin36 (Cx36) contributes to control the functions of insulin-producing
cells. In this study, we investigated whether the expression of Cx36 is regulated by glucose in
insulin-producing cells. Glucose caused a significant reduction of Cx36 in ...
Cited by 21 - Related articles - BL Direct - All 7 versions

Biophysical evidence that connexin-36 forms functional gap junction channels …

- physiology.org
AP Moreno, VM Berthoud, G Perez- … - American Journal of …, 2005 - Am Physiological Soc
Connexin-36 (Cx36) is the only gap junction protein that has been unambiguously identified
in rodent pancreatic -cells. However, properties of gap junction channel unitary currents between
-cells remain unrevealed. To address whether Cx36 forms functional channels in -cells, ...
Cited by 15 - Related articles - All 4 versions

Islet-cell-to-cell communication as basis for normal insulin secretion


S Bavamian, P Klee, A Britan, C Populaire, D … - Diabetes Obes …, 2007 - interscience.wiley.com
The emergence of pancreatic islets has necessitated the development of a signalling system
for the intra- and inter-islet coordination of β cells. With evolution, this system has evolved into
a complex regulatory network of partially cross-talking pathways, whereby individual cells ...
Cited by 6 - Related articles - All 2 versions

A novel approach to in situ characterization of pancreatic ß-cells


S Speier, M Rupnik - Pflügers Archiv European Journal of Physiology, 2003 - Springer
Abstract The tissue-slice technique has enabled major insights into neural and neuroendocrine
physiology. Our aim was to adapt this technique to study the function of the endocrine
pancreas. The preparation combines an in situ approach, as in gland perfusion, with a ...
Cited by 14 - Related articles - BL Direct - All 3 versions

Lentivirus-mediated transduction of connexin cDNAs shows level-and isoform- …

- biologists.org
D Caton, A Calabrese, C Mas, V Serre-Beinier, … - Journal of cell …, 2003 - jcs.biologists.org
We have generated novel lentiviral vectors to integrate various connexin cDNAs into
primary, non-dividing cells. We have used these vectors to test whether proper control of insulin
secretion depends on a specific connexin isoform and/or on its level of expression. We ...
Cited by 30 - Related articles - BL Direct - All 5 versions

KATP-channels in beta-cells in tissue slices are directly modulated by millimolar …


S Speier, SB Yang, K Sroka, T Rose, M Rupnik - Molecular and cellular …, 2005 - Elsevier
In pancreatic beta-cells, inhibition of K ATP -channels plays a pivotal role in signal transduction
of glucose-induced insulin release. However, the extreme sensitivity of K ATP -channels to its
ligand ATP as found in inside-out patches is not directly compatible with modulation of ...
Cited by 15 - Related articles - All 3 versions

Beta cells preferentially exchange cationic molecules via connexin 36 gap junction …


E Charpantier, J Cancela, P Meda - Diabetologia, 2007 - Springer
Abstract Aims/hypothesis Pancreatic beta cells are connected by gap junction channels made
of connexin 36 (Cx36), which permit intercellular exchanges of current-carrying ions (ionic
coupling) and other molecules (metabolic coupling). Previ- ous studies have suggested ...
Cited by 10 - Related articles - BL Direct - All 2 versions

Critical Role of Gap Junction Coupled K ATP Channel Activity for Regulated Insulin …


JV Rocheleau, MS Remedi, B Granada, WS Head, JC … - biology.plosjournals.org
The soil nematodes Caenorhabditis briggsae and Caenorhabditis elegans diverged from a common
ancestor roughly 100 million years ago and yet are almost indistinguishable by eye. They have
the same chromosome number and genome sizes, and they occupy the same ecological ...
Cited by 22 - Related articles - Cached - BL Direct - All 13 versions

Replacement by a lacZ reporter gene assigns mouse connexin36, 45 and 43 to …


M Theis, C Mas, B Döring, J Degen, C Brink, D … - Experimental cell …, 2004 - Elsevier
Transcripts of three connexin isoforms (Cx36, Cx43 and Cx45) have been reported in rodent
pancreatic islets, but the precise distribution of the cognate proteins is still unknown. We determined
expression of Cx36 in a cell-autonomous manner using mice with a targeted replacement ...
Cited by 37 - Related articles - All 3 versions


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