MG Latour, T Alquier, E Oseid, C Tremblay, TL … - Diabetes, 2007 - Am Diabetes Assoc Long-chain fatty acids amplify insulin secretion from the pancreatic β-cell.
The G-protein–coupled receptor GPR40 is specifically expressed in β-cells and
is activated by fatty acids; however, its role in acute regulation of ... Cited by 47 - Related articles - BL Direct - All 6 versions
- ►cell.com P Steneberg, N Rubins, R Bartoov-Shifman, … - Cell metabolism, 2005 - Elsevier Obesity is typically associated with elevated levels of free fatty acids (FFAs)
and is linked to glucose intolerance and type 2 diabetes. FFAs exert divergent
effects on insulin secretion from β cells: acute exposure to FFAs ... Cited by 113 - Related articles - All 11 versions
CP Briscoe, AJ Peat, SC McKeown, DF Corbett … - British journal of pharmacology, 2006 - pubmedcentral.nih.gov Long chain fatty acids have recently been identified as agonists for the G
protein-coupled receptors GPR40 and GPR120. Here, we present the first
description of GW9508, a small-molecule agonist of the fatty acid receptors ... Cited by 49 - Related articles - BL Direct - All 7 versions
M Kebede, T Alquier, MG Latour, M Semache, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The G-protein–coupled receptor GPR40 is expressed in pancreatic
β-cells and is activated by long-chain fatty acids. Gene deletion studies have
shown that GPR40 mediates, at least in part, fatty acid–amplification of ... Cited by 13 - Related articles - All 4 versions
- ►diabetesjournals.org CP Tan, Y Feng, YP Zhou, GJ Eiermann, A … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Acute activation of G protein–coupled receptor 40 (GPR40) by free
fatty acids (FFAs) or synthetic GPR40 agonists enhances insulin secretion.
However, it is still a matter of debate whether activation of GPR40 would ... Cited by 17 - Related articles - All 5 versions
H Shapiro, S Shachar, I Sekler, M … - Biochemical and Biophysical Research …, 2005 - Elsevier GPR40 is a G protein-coupled receptor expressed preferentially in β cells, that
has been implicated in mediating free fatty acid-stimulated insulin release.
GPR40 RNAi impaired the ability of palmitic acid (PA) to increase both ... Cited by 50 - Related articles - All 5 versions
S Schnell, M Schaefer, C Schöfl - Molecular and cellular endocrinology, 2007 - Elsevier Free fatty acids (FFA) cause a rise in cytosolic free Ca 2+ ([Ca 2+ ] i ) and
stimulate insulin release from pancreatic β-cells. The G-protein coupled
receptor GPR40 can be activated by medium- and long-chain FFA. We ... Cited by 24 - Related articles - All 3 versions
- ►usu.edu [PDF] A Salehi, E Flodgren, NE Nilsson, J Jimenez- … - Cell and tissue research, 2005 - Springer Abstract Free fatty acids (FFA) have generally been proposed to regulate
pancreatic insulin release by an intracellular mechanism involving inhibition of
CPT-1. The recently de-orphanized G-protein coupled receptor, FFA 1 ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►endojournals.org DD Feng, Z Luo, S Roh, M Hernandez, N … - Endocrinology, 2006 - Endocrine Soc Free fatty acids (FFAs), in addition to glucose, have been shown to stimulate
insulin release through the G protein-coupled receptor (GPCR)40 receptor in
pancreatic ß-cells. Intracellular free calcium concentration ([Ca 2+ ] i ) ... Cited by 41 - Related articles - BL Direct - All 5 versions
H Lan, LM Hoos, L Liu, G Tetzloff, W Hu, SJ … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—FFAR1/GPR40 is a G-protein–coupled receptor expressed
predominantly in pancreatic islets mediating free fatty acid–induced insulin
secretion. However, the physiological role of FFAR1 remains controversial. ... Cited by 9 - Related articles - All 5 versions
