- ►shouxi.net H Zhou, T Zhang, JS Harmon, J Bryan, RP … - Diabetes, 2007 - Am Diabetes Assoc The intraislet insulin hypothesis proposes that the decrement in β-cell insulin
secretion during hypoglycemia provides an activation signal for α-cells to
release glucagon. A more recent hypothesis proposes that zinc atoms ... Cited by 12 - Related articles - BL Direct - All 5 versions
H Zhou, T Zhang, JS Harmon, J Bryan, RP … - Am Diabetes Assoc Page 1. Zinc, Not Insulin, Regulates the Rat Alpha Cell Response to Hypoglycemia
in vivo Received for publication on 16 October 2006 ... Related articles
N Quoix, R Cheng-Xue, Y Guiot, PL Herrera, … - FEBS letters, 2007 - Elsevier The control of glucagon secretion by pancreatic α-cells is poorly understood,
largely because of the difficulty to recognize living α-cells. We describe a
new mouse model, referred to as GluCre-ROSA26EYFP (or GYY), allowing easy ... Cited by 3 - Related articles - All 6 versions
- ►shouxi.net SJ Bailey, MA Ravier, GA Rutter - Diabetes, 2007 - Am Diabetes Assoc The mechanism(s) by which glucose regulates glucagon secretion both acutely and
in the longer term remain unclear. Added to isolated mouse islets in the
presence of 0.5 mmol/l glucose, γ-aminobutyric acid (GABA) inhibited ... Cited by 9 - Related articles - BL Direct - All 7 versions
- ►endojournals.org H Zhou, T Zhang, E Oseid, J Harmon, N … - Endocrinology, 2007 - Endocrine Soc The intraislet insulin hypothesis has been proposed to explain absent glucagon
responses to hypoglycemia. Recently we directly confirmed this hypothesis by
restoring glucagon secretion via provision of a pancreatic artery insulin ... Cited by 6 - Related articles - BL Direct - All 4 versions
X Li, T Liao, J Zhuo - Clinical Science, 2008 - submit.clinsci.org Clinical studies have shown that patients with early Type 2 diabetes often have
elevated serum glucagon rather than insulin deficiency. Imbalance of insulin and
glucagon in favouring the latter may contribute to impaired glucose ... Cited by 6 - Related articles - Cached - BL Direct - All 7 versions
AV Gyulkhandanyan, H Lu, SC Lee, A … - Journal of Biological Chemistry, 2008 - ASBMB During insulin secretion, pancreatic α-cells are exposed to Zn 2+ released from
insulin-containing secretory granules. Although maintenance of Zn 2+ homeostasis
is critical for cell survival and glucagon secretion, very little is known ... Cited by 13 - Related articles - All 4 versions
- ►endocrinology-journals.org I Quesada, E Tuduri, C Ripoll, A Nadal - Journal of Endocrinology, 2008 - Soc Endocrinology The secretion of glucagon by pancreatic -cells plays a critical role in the
regulation of glycaemia. This hormone counteracts hypoglycaemia and opposes
insulin actions by stimulating hepatic glucose synthesis and mobilization, ... Cited by 8 - Related articles - All 3 versions
YM Leung, I Ahmed, L Sheu, RG Tsushima, … - Biochemical and Biophysical Research …, 2006 - Elsevier In low or absence of glucose, α-cells generate rhythmic action potentials and
secrete glucagon. α-Cell T-type Ca 2+ channels are believed to be pacemaker
channels, which are expected to open near the resting membrane potential ... Cited by 9 - Related articles - All 5 versions
- ►cell.com E Xu, M Kumar, Y Zhang, W Ju, T Obata, N … - Cell Metabolism, 2006 - Elsevier Excessive secretion of glucagon is a major contributor to the development of
diabetic hyperglycemia. Secretion of glucagon is regulated by various nutrients,
with glucose being a primary determinant of the rate of α cell glucagon ... Cited by 30 - Related articles - All 9 versions
