- ►diabetesjournals.org HQ Qu, A Montpetit, B Ge, TJ Hudson, C … - Diabetes, 2007 - Am Diabetes Assoc A novel type 1 diabetes locus was mapped to the interleukin-2 receptor α gene (IL2RA) on chromosome
10p15.1, encoding an important modulator of immunity. The aim of the current study was to confirm
the association of IL2RA with type 1 diabetes and to attempt further mapping of the ... Cited by 38 - Related articles - BL Direct - All 5 versions
CE Lowe, JD Cooper, T Brusko, NM Walker, DJ Smyth, … - Nature - diabetes.ufl.edu Genome-wide association studies are now identifying disease-associated chromosome
regions. However, even after convincing replication, the localization of the causal variant(s) requires
comprehensive resequencing, extensive genotyping and statistical analyses in large ... Cited by 99 - Related articles - View as HTML - BL Direct - All 10 versions
OJ Brand, CE Lowe, JM Heward, JA Franklyn, … - Clinical …, 2007 - pt.wkhealth.com Objective: A small number of immune response genes have been consistently associated with
the common autoimmune conditions. Recently, a linkage disequilibrium (LD) mapping
approach, using tag single nucleotide polymorphisms (SNPs), identified genetic ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►nih.gov A Vella, JD Cooper, CE Lowe, N Walker, S Nutland, … - The American Journal of …, 2005 - Elsevier Despite hundreds of association studies, few have been consistently replicated (Dahlman et
al. 2002; Hirschhorn et al. 2003; Ioannidis et al. 2003; Lohmueller et al. 2003). In type 1 diabetes
(T1D [MIM 222100]), only four loci have been identified and successfully replicated: the ... Cited by 137 - Related articles - All 6 versions
HP Kim, J Imbert, WJ Leonard - Cytokine and Growth Factor Reviews, 2006 - Elsevier Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned
and the first for which a receptor component was cloned. Its importance includes its multiple
actions, therapeutic potential, and lessons for receptor biology, with three components ... Cited by 42 - Related articles - All 9 versions
- ►diabetesjournals.org DJ Smyth, JD Cooper, JMM Howson, NM Walker, V … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The disease association of the common 1858C>T Arg620Trp (rs2476601) nonsynonymous
single nucleotide polymorphism (SNP) of protein tyrosine phosphatase; nonreceptor type 22
(PTPN22) on chromosome 1p13 has been confirmed in type 1 diabetes and also in other ... Cited by 16 - Related articles - All 4 versions
- ►diabetesjournals.org H Hakonarson, HQ Qu, JP Bradfield, L Marchand, CE … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—In stage 1 of our genome-wide association (GWA) study for type 1 diabetes, one
locus at 16p13 was detected (P = 1.03 × 10 −10 ) and confirmed in two additional cohorts. Here
we describe the results of testing, in these additional cohorts, 23 loci that were next in ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►joslinresearch.org [PDF] H Hakonarson, SFA Grant, JP Bradfield, L Marchand, … - Nature, 2007 - nature.com Type 1 diabetes (T1D) in children results from autoimmune destruction of pancreatic beta
cells, leading to insufficient production of insulin 1 . A number of genetic determinants of T1D
have already been established through candidate gene studies, primarily within the major ... Cited by 153 - Related articles - BL Direct - All 7 versions
J Yamanouchi, D Rainbow, P Serra, S Howlett, K … - Nature genetics, 2007 - nature.com Autoimmune diseases are thought to result from imbalances in normal immune physiology and
regulation. Here, we show that autoimmune disease susceptibility and resistance alleles on mouse
chromosome 3 (Idd3) correlate with differential expression of the key immunoregulatory ... Cited by 93 - Related articles - BL Direct - All 4 versions
DJ Smyth, JD Cooper, R Bailey, S Field, O Burren, LJ … - Nature genetics, 2006 - nature.com 2 Clinic of Diabetes, Institute of Diabetes, Nutrition and Metabolic Diseases 'N.Paulescu', Bucharest
79811, Romania. ... 3 Department of Paediatrics, University of Cambridge, Addenbrooke's
Hospital, Cambridge CB2 2XY, UK. ... 4 Department of Medical Genetics, Queen's ... Cited by 190 - Related articles - BL Direct - All 6 versions
