- ►diabetesjournals.org N Hosogai, A Fukuhara, K Oshima, Y Miyata, S Tanaka, … - Diabetes, 2007 - Am Diabetes Assoc Obesity is linked to a variety of metabolic disorders, such as insulin resistance and
atherosclerosis. Dysregulated production of fat-derived secretory factors, adipocytokines, is partly
responsible for obesity-linked metabolic disorders. However, the mechanistic role of ... Cited by 118 - Related articles - BL Direct - All 6 versions
- ►physiology.org J Ye, Z Gao, J Yin, Q He - American Journal of Physiology- …, 2007 - Am Physiological Soc Chronic inflammation and reduced adiponectin are widely observed in the white adipose tissue
in obesity. However, the cause of the changes remains to be identified. In this study, we provide
experimental evidence that hypoxia occurs in adipose tissue in obese mice and that ... Cited by 67 - Related articles - BL Direct - All 6 versions
- ►nih.gov B Wang, IS Wood, P Trayhurn - Pflügers Archiv European Journal of …, 2007 - Springer CoCl 2 ) led to a reduction (up to threefold over 24 h) in adiponectin and haptoglobin mRNA
levels; adiponectin secretion also decreased. No changes were observed in TNFα
expression. In contrast, hypoxia resulted in substan- tial increases in ... Cited by 50 - Related articles - BL Direct - All 8 versions
ME Rausch, S Weisberg, P Vardhana, … - International Journal of …, 2008 - digestivo.fmed.edu.uy Background: Obesity is currently viewed as a state of chronic low-grade inflammation in which
there is a pro-inflammatory alteration in the serum adipocytokine profile as well as an infiltration
of white adipose tissue by activated macrophages. The etiology of this inflammation, ... Cited by 52 - Related articles - View as HTML - BL Direct - All 5 versions
B Chen, KSL Lam, Y Wang, D Wu, MC Lam, J Shen … - … and Biophysical Research …, 2006 - Elsevier Low plasma levels of adiponectin (hypoadiponectinemia) and elevated circulating concentrations
of plasminogen activator inhibitor (PAI)-1 are causally associated with obesity-related insulin
resistance and cardiovascular disease. However, the mechanism that mediates the ... Cited by 65 - Related articles - All 6 versions
P Trayhurn, B Wang, IS Wood - British Journal of Nutrition, 2008 - Cambridge Univ Press White adipose tissue is a key endocrine and secretory organ, releasing multiple adipokines,
many of which are linked to inflammation and immu- nity. During the expansion of adipose tissue
mass in obesity there is a major inflammatory response in the tissue with increased ... Cited by 41 - Related articles - All 3 versions
- ►jlr.org MF Gregor, GS Hotamisligil - The Journal of Lipid Research, 2007 - ASBMB In the context of obesity and its related maladies, the adipocyte plays a central role in the
balance, or imbalance, of metabolic homeostasis. An obese, hypertrophic adipocyte is challenged
by many insults, including surplus energy, inflammation, insulin resistance, and ... Cited by 78 - Related articles - All 5 versions
- ►nih.gov I Stuart Wood, B Wang, S Lorente-Cebrián, P … - … and biophysical research …, 2007 - Elsevier Hypoxia modulates the production of key inflammation-related adipokines and may underlie
adipose tissue dysfunction in obesity. Here we have examined the effects of hypoxia on glucose
transport by human adipocytes. Exposure of adipocytes to hypoxia (1% O 2 ) for up to 24 ... Cited by 14 - Related articles - All 8 versions
- ►diabetesjournals.org KJ Strissel, Z Stancheva, H Miyoshi, JW Perfield, J … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Frequency of adipocyte death in eAT increased from <0.1% at baseline to 16% at
week 12, coincident with increases in 1) depot weight; 2) AT macrophages (ATMΦs) expressing
F4/80 and CD11c; 3) mRNA for tumor necrosis factor (TNF)-α, monocyte chemotactic ... Cited by 67 - Related articles - BL Direct - All 5 versions
KE Inouye, H Shi, JK Howard, CH Daly, GM Lord, BJ … - Diabetes, 2007 - Am Diabetes Assoc Macrophage recruitment to adipose tissue in obesity contributes to enhanced adipose tissue
inflammatory activity and thus may underlie obesity-associated metabolic dysfunction. Obese
adipose tissue exhibits increases in CC chemokine ligand 2 (CCL2, or monocyte ... Cited by 59 - Related articles - BL Direct - All 5 versions
