MC Puertas, J Carrillo, X Pastor, RM Ampudia, A Alba, … - Diabetes, 2007 - Am Diabetes Assoc B-cells participate in the autoimmune response that precedes the onset of type 1 diabetes, but
how these cells contribute to disease progression is unclear. In this study, we analyzed the phenotype
and functional characteristics of islet-infiltrating B-cells in the diabetes-prone NOD mouse ... Cited by 1 - Related articles - BL Direct - All 6 versions
FS Wong, L Wen - The Review of Diabetic Studies, 2005 - pubmedcentral.nih.gov Autoantibodies have been used as good markers for the prediction of future development of
type 1 diabetes mellitus (T1DM), but are not thought to be pathogenic in this disease. The role
of B cells that produce autoantibodies in the pathogenesis of human T1DM is largely ... Cited by 8 - Related articles - All 6 versions
DJ Moore, H Noorchashm, TH Lin, SA Greeley, A Naji - Diabetes, 2005 - Am Diabetes Assoc Although it is well established that B-cells are required for the development of diabetes in the
nonobese diabetic (NOD) mouse, the nature of their role remains unknown. Herein, we investigate
the hypothesis that B-cells in this autoimmune background actively disrupt the tolerant ... Cited by 4 - Related articles - All 10 versions
JM Pleau, PN Marche, MP INIESTA SERRANO, C … - Molecular immunology, 1993 - cat.inist.fr Evidence for antigen driven selection in two monoclonal auto-antibodies derived from
nonobese diabetic mice. JM PLEAU, PN MARCHE, MP INIESTA SERRANO, C BOITARD,
JF BACH Molecular immunology 30:1414, 1257-1264, Elsevier, 1993. ... Cited by 5 - Related articles - BL Direct - All 2 versions
PL Kendall, EJ Woodward, C Hulbert, … - European journal of …, 2004 - interscience.wiley.com Type 1 diabetes mellitus (T1DM) results from autoimmune destruction of insulin-producing beta
cells in the pancreatic islets. Although T1DM is mediated by T lymphocytes, B lymphocytes are
essential for insulitis and disease progression in the non-obese diabetic mouse model. ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org J Carrillo, MC Puertas, A Alba, RM Ampudia, X Pastor, … - Diabetes, 2005 - Am Diabetes Assoc B-cells accumulate in pancreatic islets during the autoimmune response that precedes the onset
of type 1 diabetes. However, the role and antigenic specificity of these cells remain a
mystery. To elucidate the antigenic repertoire of islet-infiltrating B-cells in type 1 diabetes, ... Cited by 14 - Related articles - All 6 versions
- ►diabetesjournals.org S Hussain, KV Salojin, TL Delovitch - Diabetes, 2004 - Am Diabetes Assoc B-cells proliferate after B-cell receptor (BCR) stimulation and are deleted by activation-induced
cell death (AICD) during negative selection. We report that B-cells from type 1 diabetes−susceptible
NOD and type 1 diabetes−resistant but insulitis-prone congenic NOD.B6Idd4B and NOR ... Cited by 16 - Related articles - BL Direct - All 5 versions
F Saravia, F Homo-Delarche - Trends in immunology, 2003 - Elsevier Type 1 diabetes (T1D) is thought to result from autoimmune β-cell destruction. Despite extensive
investigation, mainly in non-obese diabetic (NOD) mice, the etiology of T1D remains unknown
[1]. However, recent data support the notion that innervation is an early target in its ... Cited by 9 - Related articles - All 5 versions
S Durant, S Geutskens, SCA van Blokland, J … - Laboratory …, 2003 - nature.com The mouse pancreas, an immature organ at birth, reaches its adult size and morphology after
weaning (3 weeks of age). Around this time, apoptotic phenomena and various types of macrophages
are normally present. During development, Fas–Fas ligand (FasL) interactions are known ... Cited by 9 - Related articles - BL Direct - All 4 versions
BA Dore, WM Grogan, GE Madge, SR Webb - Neonatology, 1981 - content.karger.com Conventional biochemical and histological methods along with DNA flow-cytometric analysis
were used (1) to define development of the mouse pancreas from birth to day 90 and (2) to provide
information critical for studies on isolated islets and their component cells. Pancreas ... Cited by 9 - Related articles - All 3 versions
