- ►shouxi.net H Zhao, M Przybylska, I Wu… - Diabetes, 2007 - Am Diabetes Assoc Previous reports have shown that glycosphingolipids can modulate the activity of
the insulin receptor, and studies in transgenic mice suggest a link between
altered levels of various gangliosides and the development of insulin ... Cited by 29 - Related articles - BL Direct - All 6 versions
- ►shouxi.net JM Aerts, R Ottenhoff, AS Powlson, A Grefhorst … - Diabetes, 2007 - Am Diabetes Assoc A growing body of evidence implicates ceramide and/or its glycosphingolipid
metabolites in the pathogenesis of insulin resistance. We have developed a
highly specific small molecule inhibitor of glucosylceramide synthase, an ... Cited by 41 - Related articles - BL Direct - All 5 versions
- ►pnas.org K Kabayama, T Sato, K Saito, N Loberto, A … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Membrane microdomains (lipid rafts) are now recognized as critical for proper
compartmentalization of insulin signaling. We previously demonstrated that, in
adipocytes in a state of TNFα-induced insulin resistance, the inhibition ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org K Kabayama, T Sato, F Kitamura, S Uemura, … - Glycobiology, 2005 - Soc Glycobiology Membrane microdomains (lipid rafts) are now recognized as critical for proper
compartmentalization of insulin signaling, but their role in the pathogenesis of
insulin resistance has not been investigated. Detergent-resistant membrane ... Cited by 49 - Related articles - BL Direct - All 7 versions
M van Eijk, J Aten, N Bijl, R Ottenhoff, … - PLoS One, 2009 - pubmedcentral.nih.gov Adipose tissue is a critical mediator in obesity-induced insulin resistance.
Previously we have demonstrated that pharmacological lowering of
glycosphingolipids and subsequently GM3 by using the iminosugar AMP-DNM, ... Cited by 7 - Related articles - All 6 versions
- ►uva.nl [PDF] K Ghauharali-van der Vlugt, M Langeveld, A … - Clinica Chimica Acta, 2007 - Elsevier The ceramide concentration in plasma of untreated Gaucher patients was slightly
but not significantly lower than in controls (median: 9.8 µmol/L, range:
5.7–14.7 µmol/L, (n = 40) vs. median: 11.0 µmol/L, range: 5.1–18.0 ... Cited by 13 - Related articles - All 3 versions
- ►sciencemag.org S Tagami, J Inokuchi, K Kabayama, H … - Journal of Biological Chemistry, 2002 - ASBMB Gangliosides are known as modulators of transmembrane signaling by regulating
various receptor functions. We have found that insulin resistance induced by
tumor necrosis factor-α (TNF-α) in 3T3-L1 adipocytes was accompanied by ... Cited by 101 - Related articles - BL Direct - All 6 versions
N Bijl, CP van Roomen, V Triantis, M … - Hepatology, 2009 - interscience.wiley.com Recent reports indicate that glycosphingolipids play an important role in
regulation of carbohydrate metabolism. We have shown that the iminosugar N-(5
-adamantane-1 -yl-methoxy)-pentyl-1-deoxynojirimycin (AMP-DNM), an ... Cited by 3 - Related articles - All 2 versions
T Sato, Y Nihei, M Nagafuku, S Tagami, R … - Obesity Research & Clinical Practice, 2008 - Elsevier Study 1: serum GM3 levels were higher in hyperglycemic patients (1.4-fold),
hyperlipidemic patients (1.4-fold) and hyperglycemic patients with
hyperlipidemia (1.6-fold), than in normal subjects. Study 2: serum GM3 ... Cited by 3 - Related articles
E Zigmond, SW Zangen, O Pappo, M Sklair-Levy … - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc A link between altered levels of various gangliosides and the development of
insulin resistance was described in transgenic mice. Naturally occurring
glycosphingolipids were shown to exert immunomodulatory effects in a ... Cited by 5 - Related articles - All 3 versions
