- ►diabetesjournals.org JB Flowers, ME Rabaglia, KL Schueler, MT Flowers, H … - Diabetes, 2007 - Am Diabetes Assoc The lipogenic gene stearoyl-CoA desaturase (SCD)1 appears to be a promising new target for
obesity-related diabetes, as mice deficient in this enzyme are resistant to diet- and leptin
deficiency–induced obesity. The BTBR mouse strain replicates many features of insulin ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►nih.gov R Gutiérrez-Juárez, A Pocai, C Mulas, H … - Journal of Clinical …, 2006 - Am Soc Clin Investig Stearoyl-CoA desaturase–1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids from
saturated fatty acids. Mice with a targeted disruption of Scd1 gene locus are lean and display
increased insulin sensitivity. To examine whether Scd1 activity is required for the ... Cited by 70 - Related articles - BL Direct - All 7 versions
- ►cell.com M Miyazaki, MT Flowers, H Sampath, K Chu, C … - Cell Metabolism, 2007 - Elsevier Stearoyl-CoA desaturase-1 (SCD1), a critical regulator of energy metabolism, catalyzes the synthesis
of monounsaturated fats. To understand the tissue-specific role of SCD1 in energy
homeostasis, we used Cre-lox technology to generate mice with a liver-specific knockout ... Cited by 30 - Related articles - All 6 versions
- ►nih.gov C Chen, YM Shah, K Morimura, KW Krausz, M Miyazaki … - Cell metabolism, 2008 - Elsevier To investigate the pathogenic mechanism of ulcerative colitis, a dextran sulfate sodium
(DSS)-induced acute colitis model was examined by serum metabolomic analysis. Higher levels
of stearoyl lysophosphatidylcholine and lower levels of oleoyl lysophosphatidylcholine in ... Cited by 24 - Related articles - All 6 versions
MT Flowers, AK Groen, AT Oler, MP Keller, YJ Choi, … - Journal of lipid research, 2006 - ASBMB Page 1. 1 Cholestasis and Hypercholesterolemia in SCD1-Deficient Mice Fed a
Low-Fat, High-Carbohydrate Diet Matthew T. Flowers 1,2 , Albert K. Groen 3 , Angie
Tebon Oler 1 , Mark P. Keller 1 , YounJeong Choi 4 , Kathryn ... Cited by 11 - Related articles - BL Direct - All 6 versions
- ►nih.gov G Jiang, Z Li, F Liu, K Ellsworth, Q Dallas- … - Journal of Clinical …, 2005 - Am Soc Clin Investig Effective therapies for the treatment of obesity, a key element of metabolic syndrome, are urgently
needed but currently lacking. Stearoyl-CoA desaturase–1 (SCD1) is the rate-limiting enzyme
catalyzing the conversion of saturated long-chain fatty acids into monounsaturated fatty ... Cited by 83 - Related articles - All 11 versions
AK Busch, E Gurisik, DV Cordery, M Sudlow, GS … - Diabetes, 2005 - Am Diabetes Assoc Increased availability of fatty acids causes cell death and dysfunction in β-cell lines, isolated
islets, and animal models of diabetes. From the MIN6 β-cell line, we selected two subpools that
are resistant to palmitate-induced apoptosis. Protection was not universal because ... Cited by 40 - Related articles - BL Direct - All 5 versions
A Dobrzyn, JM Ntambi - Obesity Reviews, 2005 - interscience.wiley.com Stearoyl-CoA desaturase (SCD), the rate-limiting enzyme in monounsaturated fatty acid
synthesis, has recently been shown to be the critical control point regulating hepatic lipogenesis
and lipid oxidation. As several manifestations of the metabolic syndrome and type 2 ... Cited by 45 - Related articles - All 4 versions
SK Pinnamaneni, RJ Southgate, MA Febbraio, MJ Watt - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Stearoyl CoA desaturase 1 (SCD1) is implicated in mediating obesity
and insulin resistance. Paradoxically, SCD1 converts saturated fatty acids, the lipid species implicated
in mediating insulin resistance, to monounsaturated fatty acids. The aim of the present ... Cited by 26 - Related articles - BL Direct - All 4 versions
S Zhang, Y Yang, Y Shi - Biochemical Journal, 2005 - pubmedcentral.nih.gov SCD (stearoyl-CoA desaturase) catalyses the conversion of saturated fatty acids into mono-unsaturated
fatty acids, a critical step involved in lipid metabolism and various other biological functions. In
the present study, we report the identification and characterization of a human gene that ... Cited by 18 - Related articles - All 7 versions
