- ►diabetesjournals.org N Herbach, B Rathkolb, E Kemter, L Pichl, M … - Diabetes, 2007 - Am Diabetes Assoc The novel diabetic mouse model Munich Ins2 C95S was discovered within the Munich
N-ethyl-N-nitrosourea mouse mutagenesis screen. These mice exhibit a T→A
transversion in the insulin 2 (Ins2) gene at nucleotide position 1903 in ... Cited by 32 - Related articles - BL Direct - All 6 versions
M Liu, I Hodish, CJ Rhodes, P Arvan - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences As a tool to explore proinsulin (PI) trafficking, a human PI cDNA has been
constructed with GFP fused within the C peptide. In regulated secretory cells
containing appropriate prohormone convertases, the hProCpepGFP construct ... Cited by 11 - Related articles - BL Direct - All 6 versions
- ►pnas.org J Støy, EL Edghill, SE Flanagan, H Ye, VP … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences We report 10 heterozygous mutations in the human insulin gene in 16 probands
with neonatal diabetes. A combination of linkage and a candidate gene approach
in a family with four diabetic members led to the identification of the ... Cited by 72 - Related articles - BL Direct - All 11 versions
- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell science, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might
contribute to β-cell loss in type 2 diabetes via the induction of endoplasmic
reticulum (ER) stress. We studied here the molecular mechanisms implicated ... Cited by 23 - Related articles - All 5 versions
- ►jbc.org SH Nakagawa, Q Hua, SQ Hu, W Jia, S Wang, … - Journal of Biological Chemistry, 2006 - ASBMB Insulin contains a -turn (residues B20-B23) interposed between two
receptor-binding elements, the central -helix of the B chain (B9-B19) and its
C-terminal -strand (B24-B28). The turn contains conserved glycines at B20 ... Cited by 15 - Related articles - BL Direct - All 5 versions
- ►physiology.org S Lee, R Muniyappa, X Yan, H Chen, LQ Yue … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Insulin resistance contributes to the pathophysiology of diabetes, obesity, and
their cardiovascular complications. Mouse models of these human diseases are
useful for gaining insight into pathophysiological mechanisms. The ... Cited by 16 - Related articles - BL Direct - All 3 versions
H Elouil, M Bensellam, Y Guiot, D Vander … - Diabetologia, 2007 - Springer Page 1. ARTICLE Acute nutrient regulation of the unfolded protein response and
integrated stress response in cultured rat pancreatic islets ... Cited by 18 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org MC Akerfeldt, J Howes, JY Chan, VA Stevens, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Cytokines and palmitate triggered ER stress in β-cells as evidenced
by increased phosphorylation of PKR-like ER kinase (PERK), eukaryotic initiation
factor (EIF)2α, and Jun NH 2 -terminal kinase (JNK) and increased ... Cited by 9 - Related articles - All 3 versions
T Yoshinaga, K Nakatome, J Nozaki, M Naitoh … - Biological Chemistry, 2005 - reference-global.com 1 Department of Health and Environmental Sciences, Kyoto University Graduate
School of Medicine, Kyoto 606-8501, Japan 2 Department of Molecular and Cellular
Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto ... Cited by 9 - Related articles - BL Direct - All 6 versions
- ►shouxi.net C Huang, C Lin, L Haataja, T Gurlo, AE Butler … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Endoplasmic reticulum (ER) stress–induced apoptosis may be a
common cause of cell attrition in diseases characterized by misfolding and
oligomerisation of amyloidogenic proteins. The islet in type 2 diabetes is ... Cited by 55 - Related articles - BL Direct - All 5 versions
