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Scholar Results 1 - 10 of about 101 related to Michael: Human insulin vesicle dynamics during pulsatile secretion. (0.10 sec) 

Human insulin vesicle dynamics during pulsatile secretion

- diabetesjournals.org
DJ Michael, W Xiong, X Geng, P Drain, RH … - Diabetes, 2007 - Am Diabetes Assoc
In healthy individuals, plasma insulin levels oscillate in both fasting and fed
states. Numerous studies of isolated pancreata and pancreatic islets support the
hypothesis that insulin oscillations arise because the underlying rate of ...
Cited by 8 - Related articles - BL Direct - All 5 versions

[PDF] A novel construct to study the pulsatility of insulin secretion in single cells, islets, and whole …


V Shanmuganathan, 2008 - digitallibrary.usc.edu
Page 1. A NOVEL CONSTRUCT TO STUDY THE PULSATILITY OF INSULIN SECRETION IN SINGLE
CELLS, ISLETS, AND WHOLE PANCREAS by Vivekanandan Shanmuganathan ...
Related articles - View as HTML - All 2 versions

[PDF] Cyclic AMP oscillations in insulin-secreting cells


J Sågetorp - uu.diva-portal.org
Dissertation presented at Uppsala University to be publicly examined in B21,
BMC, Husargatan 3, Uppsala, Saturday, March 21, 2009 at 09:15 for the degree of
Doctor of Philosophy (Faculty of Medicine). The examination will be ...
Related articles - View as HTML - All 2 versions

Imaging a target of Ca2+ signalling: Dense core granule exocytosis viewed by total internal …

- nih.gov
MA Ravier, T Tsuboi, GA Rutter - Methods, 2008 - Elsevier
Ca 2+ ions are the most ubiquitous second messenger found in all cells, and play
a significant role in controlling regulated secretion from neurons, endocrine,
neuroendocrine and exocrine cells. Here, we describe microscopic techniques ...
Related articles - All 6 versions

Unifying concepts in stimulus-secretion coupling in endocrine cells and some implications …


S Misler - Advances in Physiology Education, 2009 - Am Physiological Soc
Stimulus-secretion coupling (SSC) in endocrine cells remains underappreciated as
a subject for the study/teaching of general physiology. In the present article,
we review key new electrophysiological, electrochemical, and fluorescence ...
Related articles - All 2 versions

Exocytotic Properties of Human Pancreatic β-cells


M Braun, R Ramracheya, PR Johnson, P … - Annals of the New York Academy of Sciences, 2009 - interscience.wiley.com
Pancreatic β-cells secrete insulin in response to elevated blood glucose via Ca
2+ -dependent fusion of secretory granules with the plasma membrane (regulated
exocytosis). While exocytosis has been extensively investigated in rodent ...
Related articles - All 4 versions

Temperature-sensitive random insulin granule diffusion is a prerequisite for recruiting …


R Ivarsson, S Obermuller, GA Rutter, J … - Traffic, 2004 - interscience.wiley.com
Glucose-evoked insulin secretion exhibits a biphasic time course and is
associated with accelerated intracellular granule movement. We combined live
confocal imaging of EGFP-labelled insulin granules with capacitance ...
Cited by 17 - Related articles - BL Direct - All 3 versions

Fluorescent cargo proteins in pancreatic β-cells: design determines secretion kinetics at …

- nih.gov
DJ Michael, X Geng, NX Cawley, YP Loh, CJ … - Biophysical Journal, 2004 - Elsevier
We compared secretion kinetics for four different fluorescent cargo proteins,
each targeted to the lumen of insulin secretory vesicles. Upon stimulation,
individual vesicles displayed one of four distinct patterns of fluorescence ...
Cited by 27 - Related articles - BL Direct - All 8 versions

Phasic and tonic modes of depolarization-exocytosis coupling in beta-cells of porcine islets …


S Misler, AM Silva, D Barnett, AS Dickey - Channels (Austin, Tex.), 2009 - ncbi.nlm.nih.gov
In response to depolarizations that open voltage dependent Ca(2+) channels
single porcine beta-cells display heterogeneous time courses of exocytosis. Some
cells display phasic exocytosis that is triggered by individual or short ...
Cited by 1 - Related articles - All 3 versions

Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal …

- physiology.org
AV Matveyenko, JD Veldhuis, PC Butler - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc
It has previously been shown that insulin is secreted in discrete secretory
bursts by sampling directly from the portal vein in the dog and humans.
Deficient pulsatile insulin secretion is the basis for impaired insulin ...
Cited by 1 - Related articles - All 4 versions


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