- ►diabetesjournals.org JA Emamaullee, L Stanton, C Schur, AM Shapiro - Diabetes, 2007 - Am Diabetes Assoc Islet transplantation can provide insulin independence in patients with type 1 diabetes, but islets
derived from two or more donors are often required. A significant fraction of the functional islet
mass is lost to apoptosis in the immediate posttransplant period. The caspase inhibitor N- ... Cited by 21 - Related articles - BL Direct - All 5 versions
JA Emamaullee, J Davis, R Pawlick, C Toso, S Merani, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Clinical islet transplantation can provide insulin independence in patients with
type 1 diabetes, but chronic graft failure has been observed. This has been attributed in part
to loss of ≥60% of the transplanted islets in the peritransplant period, resulting in a ... Cited by 5 - Related articles - All 4 versions
- ►endojournals.org S Merani, W Truong, JA Emamaullee, C Toso, LB … - Endocrinology, 2008 - Endocrine Soc The current scarcity of high-quality deceased pancreas donors prevents widespread application
of islet transplantation for treatment of labile type 1 diabetes mellitus. Opportunities for the improvement
of current techniques include optimization of islet isolation and purification, use of culture ... Cited by 5 - Related articles - All 4 versions
JA Emamaullee, RV Rajotte, P Liston, RG Korneluk, … - Diabetes, 2005 - Am Diabetes Assoc The Edmonton Protocol for treatment of type 1 diabetes requires islets from two or more donors
to achieve euglycemia in a single recipient, primarily because soon after portal infusion, the majority
of the transplanted cells undergo apoptosis due to hypoxia and hypoxia reperfusion ... Cited by 24 - Related articles - BL Direct - All 8 versions
M Montolio, T Noelia, B Montserrat, J Soler, E … - Cell …, 2005 - ingentaconnect.com Page 1. Cell Transplantation, Vol. 14, pp. 59–65, 2005 0963-6897/05 $20.00 + .00 Printed in
the USA. All rights reserved. Copyright 2005 Cognizant Comm. Corp. www.
cognizantcommunication.com Short-Term Culture With the Caspase Inhibitor z-VAD.fmk Reduces ... Cited by 9 - Related articles - BL Direct - All 2 versions
[CITATION] International multicenter trial of islet transplantation with the Edmonton protocol in …
MS Hanson, A Steffen, JS Danobeitia, B Ludwig … - Cell …, 2008 - ingentaconnect.com The objective of this study was to develop a multiparametric flow cytometry assay to simultaneously
quantify isolated pancreatic islet cell viability, apoptosis, and glucose-induced metabolic
flux. INS-1 and rat islet β-cells were stained with fluorescent probes for cell viability ... Cited by 3 - Related articles
M Pedulla, R d'Aquino, V Desiderio, F de … - Journal of cellular …, 2007 - interscience.wiley.com Pancreatic islets are commonly isolated for research and transplantation without taking into consideration
that they undergo mechanical or chemical stress during this process. In order to counteract both
types of injuries, the compound AEOL10150, a novel MnSOD mimic, was added during ... Cited by 4 - Related articles - BL Direct - All 4 versions
D Yin, JW Ding, J Shen, L Ma, M Hara, AS … - American Journal of …, 2006 - ccmjournal.org From University Health Network, Women's Health Program (JIC, AMC), Inter-Departmental Division
of Critical Care Medicine (MSH), Department of Medicine (MSH, CMT, AMC), and Krembil Neuroscience
Program (MPM); University of Toronto, Institute of Medical Science (JIC, MSH, CMT), ... Cited by 17 - Related articles - BL Direct - All 4 versions
JA Emamaullee, AM Shapiro - Cell Transplantation, 2007 - ingentaconnect.com Recent advances in clinical islet transplantation have clearly demonstrated that this procedure
can provide excellent glycemic control and often insulin independence in a population of patients
with type 1 diabetes. A key limitation in the widespread application of clinical islet ... Cited by 30 - Related articles - BL Direct - All 2 versions
