N Weinberg, L Ouziel-Yahalom, S Knoller, S … - Diabetes, 2007 - Am Diabetes Assoc Understanding and manipulating pancreatic β-cell proliferation is a major
challenge for pancreas biology and diabetes therapy. Recent studies have raised
the possibility that human β-cells can undergo dedifferentiation and give ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org F Atouf, CH Park, K Pechhold, M Ta, Y Choi, … - Diabetes, 2007 - Am Diabetes Assoc We used cre/loxP-based genetic lineage tracing analysis to test a previously
proposed hypothesis that in vitro cultured adult pancreatic β-cells undergo
epithelial-mesenchymal transition (EMT) to generate a highly proliferative, ... Cited by 30 - Related articles - BL Direct - All 5 versions
LG Chase, F Ulloa-Montoya, BL Kidder, CM … - Diabetes, 2007 - Am Diabetes Assoc As recent studies suggest that newly formed pancreatic β-cells are a result of
self-duplication rather than stem cell differentiation, in vitro expansion of
β-cells presents a potential mechanism by which to increase available ... Cited by 41 - Related articles - BL Direct - All 7 versions
- ►nih.gov RA Morton, E Geras-Raaka, LM Wilson, BM … - Molecular and cellular endocrinology, 2007 - Elsevier We previously presented evidence that proliferative human islet precursor cells
may be derived in vitro from adult islets by epithelial-to-mesenchymal
transition (EMT) and show here that similar fibroblast-like cells can be ... Cited by 28 - Related articles - All 5 versions
L Ouziel-Yahalom, M Zalzman, L Anker-Kitai, S … - Biochemical and Biophysical Research …, 2006 - Elsevier Type 1 diabetes is caused by autoimmune destruction of the pancreatic islet
insulin-producing β cells. Insulin administration does not prevent long-term
complications of the disease, since the optimal insulin dosage is difficult ... Cited by 52 - Related articles - All 4 versions
- ►alphamedpress.org B Davani, L Ikonomou, BM Raaka, E Geras- … - Stem Cells, 2007 - AlphaMed Press Islet transplantation offers improved glucose homeostasis in diabetic patients,
but transplantation of islets is limited by the supply of donor pancreases.
Undifferentiated precursors hold promise for cell therapy because they can ... Cited by 27 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org HA Russ, Y Bar, P Ravassard, S Efrat - Diabetes, 2008 - Am Diabetes Assoc RESULTS— β-Cells were efficiently and specifically labeled by the dual virus
system. Label + , insulin − cells derived from β-cells were shown to
proliferate for a maximum of 16 population doublings, with an approximate ... Cited by 19 - Related articles - All 4 versions
R Gallo, F Gambelli, B Gava, F Sasdelli, V … - Cell Death & Differentiation, 2007 - nature.com Cellular models and culture conditions for in vitro expansion of
insulin-producing cells represent a key element to develop cell therapy for
diabetes. Initial evidence that human -cells could be expanded after ... Cited by 13 - Related articles - BL Direct - All 5 versions
AG Kayali, LE Flores, AD Lopez, B Kutlu, E … - Diabetes, 2007 - Am Diabetes Assoc Limited organ availability is an obstacle to the widespread use of islet
transplantation in type 1 diabetic patients. To address this problem, many
studies have explored methods for expanding functional human islets in ... Cited by 18 - Related articles - BL Direct - All 5 versions
MC Gershengorn, AA Hardikar, C Wei, E … - Science, 2004 - sciencemag.org Insulin-expressing beta cells, found in pancreatic islets, are capable of
generating more beta cells even in the adult. We show that fibroblast-like cells
derived from adult human islets donated postmortem proliferate readily in ... Cited by 182 - Related articles - All 11 versions
