- ►diabetesjournals.org B Zhang, Y Lu, M Campbell-Thompson, T … - Diabetes, 2007 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease resulting from destruction of the
insulin-producing islet β-cells (1). Multiple lines of evidence indicate that
antigen-presenting cells (APCs), especially dendritic cells, are ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] EC Lewis, L Shapiro, OJ Bowers, CA … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Islet transplantation for type 1 diabetic patients shows promising results with
the use of nondiabetogenic immunosuppressive therapy. However, in addition to
compromising the immune system of transplant recipients, long-term studies ... Cited by 41 - Related articles - BL Direct - All 7 versions
- ►pnas.org EC Lewis, M Mizrahi, M Toledano, N DeFelice, … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Human pancreatic islet transplantation offers diabetic patients tight glucose
control but has low graft survival rates. The immunosuppressive drugs that are
administered to graft recipients lack the antiinflammatory benefits of ... Cited by 5 - Related articles - All 8 versions
- ►shouxi.net B Zhang, Y Lu, M Campbell-Thompson, T … - Diabetes, 2007 - Am Diabetes Assoc -Cell apoptosis appears to represent a key event in the pathogenesis of type 1
diabetes. Previous studies have demonstrated that administration of the serine
proteinase inhibitor 1-antitrypsin (AAT) prevents type 1 diabetes ... Cited by 5 - Related articles - All 2 versions
S Song, K Goudy, M Campbell-Thompson, C … - Gene Therapy, 2004 - nature.com Type I diabetes results from an autoimmune destruction of the insulin-producing
pancreatic cells. Although the exact immunologic processes underlying this
disease are unclear, increasing evidence suggests that immunosuppressive, ... Cited by 36 - Related articles - BL Direct - All 3 versions
- ►pnas.org M Koulmanda, M Bhasin, L Hoffman, Z Fan, A … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Invasive insulitis is a destructive T cell-dependent autoimmune process directed
against insulin-producing β cells that is central to the pathogenesis of type 1
diabetes mellitus (T1DM) in humans and the clinically relevant nonobese ... Cited by 5 - Related articles - All 5 versions
GB Pott, ED Chan, CA Dinarello, L Shapiro - Journal of Leukocyte Biology, 2009 - jleuk.highwire.org Several observations suggest endogenous suppressors of inflammatory mediators
are present in human blood. -1-Antitrypsin (AAT) is the most abundant serine
protease inhibitor in blood, and AAT possesses anti-inflammatory activity ... Cited by 3 - Related articles - All 5 versions
GC Weir, M Koulamnda - Current Diabetes Reports, 2009 - Springer Controlling immune destruction of pancreatic β cells is a critically important
challenge for diabetes research. The study of mechanisms of autoimmunity in type
1 diabetes and the rejection of transplanted islets has focused on the ... Cited by 2 - Related articles - All 2 versions
RD Molano, A Pileggi, S Song, E Zahr, S San … - Transplantation Proceedings, 2008 - mac.com ABSTRACT Immunomodulatory properties have been recognized for human alpha-1
antitrypsin (hAAT). However, production of anti-hAAT antibodies in mice may
inactivate the protein. In this study, we evaluated the effects of chronic ... Cited by 1 - Related articles - View as HTML - All 10 versions
