- ►diabetesjournals.org CY Lin, T Gurlo, R Kayed, AE Butler, L … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Islets in type 2 diabetes are characterized by a deficit in
β-cells, increased β-cell apoptosis, and islet amyloid derived from islet
amyloid polypeptide (IAPP). The toxic form of amyloidogenic protein ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org S Zhang, H Liu, H Yu, GJS Cooper - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS— We measured responses to hA in isolated mouse
islets and two insulinoma cell lines, wherein we measured Fas/Fas ligand (FasL)
and Fas-associated death domain (FADD) expression by quantitative RT-PCR, ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org [PDF] CY Lin, T Gurlo, R Kayed, AE Butler, L … - Diabetes, 2007 - Am Diabetes Assoc Page 1. Toxic Human IAPP Oligomers are Intracellular, and Vaccination to
Induce Anti- toxic Oligomer Antibodies Does not Prevent ... Cited by 2 - Related articles - All 2 versions
- ►physiology.org JJ Meier, R Kayed, CY Lin, T Gurlo, L … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Type 2 diabetes mellitus (T2DM) is characterized by an 60% deficit in -cell
mass, increased -cell apoptosis, and islet amyloid derived from islet amyloid
polypeptide (IAPP). Human IAPP (hIAPP) forms oligomers, leading to either ... Cited by 32 - Related articles - BL Direct - All 3 versions
- ►shouxi.net C Huang, C Lin, L Haataja, T Gurlo, AE Butler … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Endoplasmic reticulum (ER) stress–induced apoptosis may be a
common cause of cell attrition in diseases characterized by misfolding and
oligomerisation of amyloidogenic proteins. The islet in type 2 diabetes is ... Cited by 55 - Related articles - BL Direct - All 5 versions
B Konarkowska, JF Aitken, J Kistler, S Zhang … - FEBS J, 2006 - interscience.wiley.com Human amylin is a small fibrillogenic protein that is the major constituent of
pancreatic islet amyloid, which occurs in most subjects with type 2 diabetes.
There is evidence that it can elicit in vitro apoptosis in islet β-cells, ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►shouxi.net RA Ritzel, JJ Meier, CY Lin, JD Veldhuis, PC … - Diabetes, 2007 - Am Diabetes Assoc Insulin secretion from the 2,000–3,000 β-cells in an islet is a highly
synchronized activity with discharge of insulin in coordinate secretory bursts
at approximately 4-min intervals. Insulin secretion progressively declines ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►physiology.org C Huang, L Haataja, T Gurlo, AE Butler, X Wu, … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc The islet in type 2 diabetes is characterized by an 60% β-cell deficit,
increased β-cell apoptosis, and islet amyloid derived from islet amyloid
polypeptide (IAPP). Human IAPP (hIAPP) but not rodent IAPP (rIAPP) forms ... Cited by 10 - Related articles - BL Direct - All 3 versions
- ►shouxi.net S Casas, R Gomis, FM Gribble, J Altirriba, S … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Increased expression of several heat shock proteins and activation of
the spliced form of XBP-1, a transcription factor for overexpression of
chaperones during endoplasmic reticulum (ER) stress, were detected together ... Cited by 12 - Related articles - BL Direct - All 4 versions
S Zhang, J Liu, M Dragunow, GJS Cooper - Journal of Biological Chemistry, 2003 - ASBMB Fibrillogenic human amylin elicits pancreatic -cell apoptosis that may
contribute to development of type-2 diabetes. Here, we demonstrated that
activation of a caspase cascade is necessary for induction of apoptosis by ... Cited by 37 - Related articles - BL Direct - All 4 versions
