JM Aerts, R Ottenhoff, AS Powlson, A Grefhorst … - Diabetes, 2007 - Am Diabetes Assoc A growing body of evidence implicates ceramide and/or its glycosphingolipid
metabolites in the pathogenesis of insulin resistance. We have developed a
highly specific small molecule inhibitor of glucosylceramide synthase, an ... Cited by 41 - Related articles - BL Direct - All 5 versions
H Zhao, M Przybylska, I Wu… - Diabetes, 2007 - Am Diabetes Assoc Previous reports have shown that glycosphingolipids can modulate the activity of
the insulin receptor, and studies in transgenic mice suggest a link between
altered levels of various gangliosides and the development of insulin ... Cited by 29 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org K Kabayama, T Sato, F Kitamura, S Uemura, … - Glycobiology, 2005 - Soc Glycobiology Membrane microdomains (lipid rafts) are now recognized as critical for proper
compartmentalization of insulin signaling, but their role in the pathogenesis of
insulin resistance has not been investigated. Detergent-resistant membrane ... Cited by 49 - Related articles - BL Direct - All 7 versions
PIOFG SYNTHASE, EI SENSITIVITY - Am Diabetes Assoc Johannes M. Aerts 1, Roelof Ottenhoff 2, Andrew S. Powlson 3, Aldo Grefhorst 4,
Marco van Eijk 2, Peter F. Dubbelhuis 2, Folkert Kuipers 4, Mireille J. Serlie
5, Tom Wennekes 6, Hermen S. Overkleeft 6, Jasswinder K. Sethi 3, Stephen O' ... Related articles
- ►uva.nl [PDF] K Ghauharali-van der Vlugt, M Langeveld, A … - Clinica Chimica Acta, 2007 - Elsevier The ceramide concentration in plasma of untreated Gaucher patients was slightly
but not significantly lower than in controls (median: 9.8 µmol/L, range:
5.7–14.7 µmol/L, (n = 40) vs. median: 11.0 µmol/L, range: 5.1–18.0 ... Cited by 13 - Related articles - All 3 versions
S Tagami, J Inokuchi, K Kabayama, H … - Journal of Biological Chemistry, 2002 - ASBMB Gangliosides are known as modulators of transmembrane signaling by regulating
various receptor functions. We have found that insulin resistance induced by
tumor necrosis factor-α (TNF-α) in 3T3-L1 adipocytes was accompanied by ... Cited by 101 - Related articles - BL Direct - All 6 versions
- ►pnas.org K Kabayama, T Sato, K Saito, N Loberto, A … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Membrane microdomains (lipid rafts) are now recognized as critical for proper
compartmentalization of insulin signaling. We previously demonstrated that, in
adipocytes in a state of TNFα-induced insulin resistance, the inhibition ... Cited by 34 - Related articles - BL Direct - All 6 versions
JM Aerts, R Ottenhoff, A Grefhorst, AS Powlson … - Insulin sensitivity of hepatic glucose and lipid … - dissertations.ub.rug.nl A growing body of evidence implicates ceramide and/or its glycosphingolipid
metabolites in the pathogenesis of insulin resistance. We have developed a
highly specific small molecule inhibitor of glucosylceramide synthase, an ... Related articles - View as HTML - All 4 versions
T Yamashita, A Hashiramoto, M Haluzik, H … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Gangliosides are sialic acid-containing glycosphingolipids that are present on
all mammalian plasma membranes where they participate in recognition and
signaling activities. We have established mutant mice that lack GM3 ... Cited by 151 - Related articles - BL Direct - All 9 versions
- ►endojournals.org M Langeveld, KJM Ghauharali, HP Sauerwein, … - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Context: Complex glycosphingolipids, in majority the ganglioside GM3, surround
the insulin receptor in a special membrane compartment (raft) and modulate
signaling through this receptor. Increased levels of GM3 in rafts impair ... Cited by 8 - Related articles - All 5 versions
