H Okamoto, E Latres, R Liu, K Thabet, A Murphy, D … - Diabetes, 2007 - Am Diabetes Assoc Trb3, a mammalian homolog of Drosophila tribbles, was proposed as a suppressor of Akt
activity, predominantly in conditions of fasting and diabetes. Given these prior studies, we sought
to determine whether Trb3 plays a major role in modulating hepatic insulin sensitivity. To ... Cited by 13 - Related articles - BL Direct - All 4 versions
PB Iynedjian - Biochemical Journal, 2005 - pubmedcentral.nih.gov The protein TRB3 (tribbles 3), also called NIPK (neuronal cell death-inducible protein
kinase), was recently identified as a protein–protein interaction partner and an inhibitor of PKB
(protein kinase B). To explore the hypothesis that TRB3/NIPK might act as a negative ... Cited by 28 - Related articles - All 8 versions
- ►diabetesjournals.org S Prudente, ML Hribal, E Flex, F Turchi, E Morini, S De … - Diabetes, 2005 - Am Diabetes Assoc Insulin resistance plays a major role in dyslipidemia, cardiovascular disease, and type 2
diabetes. TRB3, a mammalian tribbles homolog, whose chromosomal region 20p13-p12 has
been linked to human type 2 diabetes, impairs insulin signaling through the inhibition of ... Cited by 26 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] H Okamoto, E Latres, R Liu, K Thabet, A Murphy, D … - Diabetes, 2007 - Am Diabetes Assoc Page 1. Diabetes Okamoto et al Genetic Deletion of Trb3, the Mammalian tribbles Homolog,
Displays Normal Hepatic Insulin Signaling and Glucose Homeostasis Received for publication
15 October 2006 and accepted in revised form 6 February 2007. ... Cited by 1 - Related articles - All 2 versions
S Kato, K Du - Biochemical and Biophysical Research …, 2007 - Elsevier TRB3 is a member of TRB protein family characterized by containing a variant kinase domain
without enzymatic activity. Interacting with Ser/Thr protein kinases Akt, TRB3 impairs Akt activation
induced by growth factors and insulin. In this study we have examined the potential role of ... Cited by 19 - Related articles - All 5 versions
- ►jbc.org M Klingenspor, P Xu, RD Cohen, C Welch, K Reue - Journal of Biological …, 1999 - ASBMB The mouse fatty liver dystrophy (fld) mutation is characterized by transient hypertriglyceridemia
and fatty liver during the neonatal period, followed by development of a peripheral
neuropathy. To uncover the metabolic pathway that is disrupted by the fld mutation, we ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►nih.gov O Bezy, C Vernochet, S Gesta, SR Farmer, … - Molecular and Cellular …, 2007 - Am Soc Microbiol TRB3 has been implicated in the regulation of several biological processes in mammalian cells
through its ability to influence Akt and other signaling pathways. In this study, we investigated
the role of TRB3 in regulating adipogenesis and the activity of adipogenic transcription ... Cited by 16 - Related articles - BL Direct - All 6 versions
[CITATION] TRB3: a tfibbles homolog that inhibits Akt
- ►jbc.org T Naiki, E Saijou, Y Miyaoka, K Sekine, A Miyajima - Journal of Biological …, 2007 - ASBMB Adipocyte differentiation is regulated by a complex array of extracelluar signals, intracellular
mediators and transcription factors. Here we describe suppression of adipocyte differentiation
by TRBs, mammalian orthologs of Drosophila Tribbles. Whereas all the three TRBs were ... Cited by 14 - Related articles - All 5 versions
R Schwarzer, S Dames, D Tondera, A Klippel, J … - Cellular signalling, 2006 - Elsevier We have identified TRB3, a human homologue of Drosophila tribbles, as a novel transcriptional
target of phosphatidylinositol (PI) 3-kinase. TRB3 expression is remarkably reduced in prostate
cancer PC-3 cells after inhibition of PI 3-kinase. TRB3 expression is furthermore ... Cited by 24 - Related articles - All 4 versions
