- ►diabetesjournals.org S Prudente, E Flex, E Morini, F Turchi, D Capponi, S De … - Diabetes, 2007 - Am Diabetes Assoc Aquaporin 7 (AQP7), the gateway protein controlling glycerol release, has recently emerged
as a modulator of adipocyte metabolism. AQP7 knockout mice develop obesity and
hyperglycemia. The contribution of AQP7 to these abnormalities in humans is unknown. ... Cited by 13 - Related articles - BL Direct - All 6 versions
- ►endojournals.org V Ceperuelo-Mallafré, M Miranda, MR Chacón, … - Journal of Clinical …, 2007 - Endocrine Soc Results: Severely obese women showed lower AQP7 expression levels compared with lean
and nonseverely obese (P < 0.001). Moreover, circulating glycerol concentration was lower in
severely obese subjects, but no correlation with AQP7 adipose tissue expression was ... Cited by 10 - Related articles - BL Direct - All 6 versions
T Hibuse, N Maeda, A Nagasawa, T Funahashi - BBA-Biomembranes, 2006 - Elsevier The discovery of aquaporin (AQP) has made a great impact on life sciences. AQPs are a family
of homologous water channels widely distributed in plants, unicellular organisms,
invertebrates, and vertebrates. So far, 13 AQPs have been identified in human. AQP3, 7, ... Cited by 21 - Related articles - All 4 versions
V Catalán, J Gómez-Ambrosi, C Pastor, F Rotellar, C … - Obesity Surgery, 2008 - Springer Abstract Background Glycerol production and its efflux from adipo- cytes to the liver are key to
modulate lipid and glucose homeostasis. Aquaporin 7 (AQP7) is an aquaglyceroporin that acts
as the adipose glycerol channel, whereas aquaporin 9 (AQP9) is the specific channel ... Cited by 8 - Related articles - BL Direct - All 3 versions
H Kondo, I Shimomura, K Kishida, H … - European Journal of …, 2002 - interscience.wiley.com Aquaporin adipose (AQPap), which we identified from human adipose tissue, is a glycerol channel
in adipocyte [Kishida et al. (2000) J. Biol. Chem.275, 20896–20902]. In the current study, we
determined the genomic structure of the human AQPap gene, and identified three AQPap- ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►nih.gov N Maeda, T Funahashi, T Hibuse, A … - Proceedings of the …, 2004 - National Acad Sciences Adipocytes hydrolyze triglycerides and secrete free fatty acids and glycerol into the
circulation. The molecular mechanism involved in glycerol transport from adipocytes has not
been elucidated. Here, we investigated glycerol and glucose metabolism in mice lacking ... Cited by 53 - Related articles - All 9 versions
T Hibuse, N Maeda, T Funahashi, K … - Proceedings of the …, 2005 - National Acad Sciences In adipocytes, hydrolysis of triglycerides results in the release of free fatty acids and glycerol.
Aquaporin 7 (AQP7), a member of aquaglyceroporins, is known to permeabilize glycerol and
water. We recently generated Aqp7-knockout (KO) mice and demonstrated that such mice ... Cited by 75 - Related articles - BL Direct - All 10 versions
M Hara-Chikuma, E Sohara, T Rai, M Ikawa, M … - Journal of Biological …, 2005 - ASBMB Aquaporin-7 (AQP7) is a water/glycerol transporting protein expressed in adipocyte plasma
membranes. We report here remarkable age-dependent hypertrophy in adipocytes in
AQP7-deficient mice. Wild type and AQP7 null mice had similar growth at 0–16 weeks as ... Cited by 80 - Related articles - All 6 versions
MP Marrades, FI Milagro, JA Martínez, MJ Moreno- … - … and biophysical research …, 2006 - Elsevier Aquaporin 7 (AQP7) is an aquaglyceroprotein responsible for the secretion and uptake of glycerol
from the adipocyte. The modulation of the expression of this membrane transport protein might
play an important role in the susceptibility to the development of obesity. The aim of the ... Cited by 30 - Related articles - All 6 versions
