- ►diabetesjournals.org SS Choe, AH Choi, JW Lee, KH Kim, JJ Chung, J Park, … - Diabetes, 2007 - Am Diabetes Assoc Liver X receptor (LXR)α and LXRβ play important roles in fatty acid metabolism and cholesterol
homeostasis. Although the functional roles of LXR in the liver, intestine, fat, and macrophages
are well established, its role in pancreatic β-cells has not been clearly defined. In this ... Cited by 23 - Related articles - BL Direct - All 6 versions
- ►endojournals.org W Wente, MB Brenner, H Zitzer, J Gromada, AM Efanov - Endocrinology, 2007 - Endocrine Soc Liver X receptors (LXRs) form functional heterodimers with the retinoid X receptors (RXRs) and
regulate cholesterol, lipid, and glucose metabolism. We demonstrated previously that activation
of LXR modulates insulin secretion in MIN6 cells and pancreatic islets. In this study we ... Cited by 22 - Related articles - BL Direct - All 3 versions
SS Choe, AH Choi, JW Lee, KH Kim, JJ Chung, J Park, … - DIABETES, 2007 - Am Diabetes Assoc Page 1. Original Article Chronic Activation of Liver X Receptor Induces -Cell Apoptosis
Through Hyperactivation of Lipogenesis Liver X Receptor–Mediated Lipotoxicity
in Pancreatic -Cells Sung Sik Choe, 1 A Hyun Choi, 1 Joo ... Related articles - All 2 versions
SS Choe, AH Choi, JW Lee, KH Kim, JJ Chung, J Park … - 糖尿病学杂志, 2007 - journal.shouxi.net 【摘要】 Liver X receptor (LXR) and LXR play important roles in fatty acid metabolism and cholesterol
homeostasis. Although the functional roles of LXR in the liver, intestine, fat, and macrophages
are well established, its role in pancreatic -cells has not been clearly defined. In this ... Related articles - Cached
- ►endojournals.org H Zitzer, W Wente, MB Brenner, S Sewing, K Buschard, … - Endocrinology, 2006 - Endocrine Soc Liver X receptors (LXR and LXRß) regulate glucose and lipid metabolism. Pancreatic ß-cells
and INS-1E insulinoma cells express only the LXRß isoform. Activation of LXRß with the synthetic
agonist T0901317 increased glucose-induced insulin secretion and insulin content, ... Cited by 23 - Related articles - BL Direct - All 4 versions
- ►endojournals.org Y Liu, C Yan, Y Wang, Y Nakagawa, N Nerio, A Anghel, … - Endocrinology, 2006 - Endocrine Soc The glucocorticoid receptor (GR) is a crucial target gene for glucocorticoid-induced insulin resistance
and hepatic gluconeogenesis linked to the development of type 2 diabetes. The liver X receptors
(LXRs) are nuclear receptors that play an important role in the regulation of the metabolic ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►jbc.org T Yamamoto, H Shimano, N Inoue, Y Nakagawa, T … - Journal of Biological …, 2007 - ASBMB Sterol regulatory element-binding protein (SREBP)-1c is a transcription factor that controls synthesis
of fatty acids and triglycerides in the liver and is highly regulated by nutrition and hormones. In
the current studies we show that protein kinase A (PKA), a mediator of glucagon/cAMP, a ... Cited by 22 - Related articles - All 9 versions
I Gerin, VW Dolinsky, JG Shackman, RT Kennedy, … - Journal of Biological …, 2005 - ASBMB Liver X receptors (LXR) α and β are nuclear oxysterol receptors with established roles in
cholesterol, lipid, and carbohydrate metabolism. Although LXRs have been extensively studied
in liver and macrophages, the importance for development and metabolism of other ... Cited by 55 - Related articles - All 7 versions
- ►aspetjournals.org M Loffler, M Bilban, M Reimers, W Waldhausl, TM … - Journal of Pharmacology …, 2006 - ASPET Agonists of the nuclear receptors peroxisome proliferator-activated receptor (PPAR) , PPAR ,
and liver X receptors (LXRs) reduce blood glucose in type 2 diabetic patients and comparable
mouse models. Since the capacity of these drugs to normalize hepatic gene expression is ... Cited by 16 - Related articles - BL Direct - All 5 versions
