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Scholar Results 1 - 10 of about 101 related to Xu: Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia. (0.09 sec) 

Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia

- shouxi.net
G Xu, H Kaneto, DR Laybutt, VF Duvivier-Kali … - Diabetes, 2007 - Am Diabetes Assoc
Stimulation of insulin secretion by the incretin hormones glucagon-like peptide
1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) has been found to
be diminished in type 2 diabetes. We hypothesized that this impairment is ...
Cited by 26 - Related articles - BL Direct - All 5 versions

Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing …


S Piteau, A Olver, SJ Kim, K Winter, JA … - Biochemical and Biophysical Research …, 2007 - Elsevier
In type 2 diabetes (T2DM) β-cell responsiveness to glucose-dependent
insulinotropic polypeptide (GIP) is reduced. In a model of T2DM, the VDF Zucker
rat, GIP receptor mRNA and protein levels were shown to be down-regulated. ...
Cited by 12 - Related articles - All 4 versions

Expression of the GLP-1 receptor in mouse, rat, and human pancreas

- jhc.org
D Tornehave, P Kristensen, J Romer, LB … - Journal of Histochemistry and Cytochemistry, 2008 - Histochemical Soc
GLP-1 acts through a G protein–coupled receptor (GLP-1R) (Thorens 1992 Go ),
which is expressed in several tissues including the pancreatic islets (Bullock
et al. 1996 Go ). Using radioligand binding assays, GLP-1Rs have been ...
Cited by 5 - Related articles - All 5 versions

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta- …


M Loder, G Xavier, A McDonald, G Rutter - Biochemical Society Transactions, 2008 - biochemsoctrans.org
Key words: β-cell, diabetes, forkhead box O1 (FoxO1), insulin secretion, T-cell
factor 7-like 2 (TCF7L2), Type 2 diabetes mellitus (T2DM). ... Abbreviations
used: FoxO1, forkhead box O1; GLP-1, glucagon-like peptide 1; siRNA, small ...
Cited by 8 - Related articles - Cached - BL Direct - All 5 versions

[CITATION] Four weeks of near-normalization of blood glucose restores the insulin response to GIP and …


PV Hojberg, T Vilsboll, FK Knop… - Diabetes, 2007
Cited by 11 - Related articles

A novel pathway for regulation of glucose-dependent insulinotropic polypeptide receptor …

- fasebj.org [PDF] 
FC Lynn, SA Thompson, JA Pospisilik, JA … - The FASEB Journal, 2002 - FASEB
The FASEB Journal express article 10.1096/fj.02-0243fje. Published online
November 15, 2002. ... A novel pathway for regulation of glucose-dependent ...
Francis C. Lynn, Stephen A. Thompson, J. Andrew Pospisilik, Jan A. Ehses, ...
Cited by 29 - Related articles - BL Direct - All 6 versions

Type 2 Diabetes Susceptibility Gene TCF7L2 and Its Role in β-Cell Function

- diabetesjournals.org
AL Gloyn, M Braun, P Rorsman - Diabetes, 2009 - Am Diabetes Assoc
Type 2 diabetes is associated with impaired insulin secretion. Both 1st- and
2nd-phase insulin secretion are reduced, but the effect is particularly
pronounced for the 1st phase. The processes culminating in impaired insulin ...
Cited by 2 - Related articles - All 3 versions

Changes in glycaemic control are related to the systolic function in type 1 diabetes mellitus


NH Andersen, TK Hansen, JS Christiansen - Scandinavian Cardiovascular Journal, 2007 - ingentaconnect.com
Aim. To examine whether changes in glycaemic control are related to the left
ventricular function, in a group of type 1 diabetic patients. Methods. We
included 19 consecutive type 1 diabetic patients selected for insulin pump ...
Cited by 3 - Related articles - BL Direct - All 2 versions

Leptin but not neuropeptide Y up-regulated glucagon-like peptide 1 receptor expression in …


C Sanz, P Vázquez, MA Navas, E Alvarez, E … - Metabolism, 2008 - Elsevier
In an attempt to gain better insight into the central effects of glucagon-like
peptide (GLP-1), we studied the action of glucose and of regulatory peptides on
the expression of its receptor (GLP-1R) in hypothalamic GT1-7 cells and in ...
Cited by 3 - Related articles - All 13 versions

Stimulation of gastric inhibitory polypeptide release in ob/ob mice by oral administration of …

- nutrition.org [PDF] 
PR Flatt, P Kwasowski, CJ Bailey - Journal of Nutrition, 1989 - Am Soc Nutrition
ABSTRACT The effect of oral administration of sugars and their analogues
(glucose, galactose, fructose, man- nose, sucrose, /Y-acetylglucosamine,
2-deoxyglucose. 3- O-methylglucose and a-methyl-glucoside) on plasma gas ...
Cited by 4 - Related articles - All 4 versions


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