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Scholar Results 1 - 10 of about 101 related to Ramos: Pathogenesis of spinally mediated hyperalgesia in diabetes. (0.11 sec) 

Pathogenesis of spinally mediated hyperalgesia in diabetes

- shouxi.net
KM Ramos, Y Jiang, CI Svensson, NA Calcutt - Diabetes, 2007 - Am Diabetes Assoc
Hyperalgesia to noxious stimuli is accompanied by increased spinal
cyclooxygenase (COX)-2 protein in diabetic rats. The present studies were
initiated to establish causality between increased spinal COX-2 activity ...
Cited by 13 - Related articles - BL Direct - All 5 versions

Impaired formalin-evoked changes of spinal amino acid levels in diabetic rats


AB Malmberg, WT O'Connor, JC Glennon, R … - Brain research, 2006 - Elsevier
To investigate mechanisms by which diabetes alters sensory processing, we
measured levels of amino acid neurotransmitters in spinal dialysates from awake,
unrestrained control and diabetic rats under resting conditions and ...
Cited by 6 - Related articles - All 3 versions

Pathogenesis of pain in peripheral diabetic neuropathy

- wisc.edu [PDF] 
NA Calcutt, MM Backonja - Current Diabetes Reports, 2007 - Springer
Recent advances in understanding the pain associated with diabetic neuropathy
are likely to provide significant mechanistic insights and offer better
therapies. In clini- cal research, new tools for measuring neuropathic pain ...
Cited by 6 - Related articles - BL Direct - All 3 versions

Treatment with the xanthine oxidase inhibitor, allopurinol, improves nerve and vascular …


ME Inkster, MA Cotter, NE Cameron - European journal of pharmacology, 2007 - Elsevier
Several putative sources of reactive oxygen species could potentially contribute
to diabetic neuropathy and vasculopathy. The aim was to assess the involvement
of elevated xanthine oxidase activity. After 6 weeks of ...
Cited by 15 - Related articles - All 4 versions

Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal …

- ucsd.edu [PDF] 
CG Jolivalt, CA Lee, KM Ramos, NA Calcutt - Pain, 2008 - Elsevier
Diabetic rats show behavioral indices of painful neuropathy that may model the
human condition. Hyperalgesia during the formalin test in diabetic rats is
accompanied by the apparently paradoxical decrease in spinal release of ...
Cited by 8 - Related articles - All 17 versions

Growth factors as therapeutics for diabetic neuropathy


NA Calcutt, CG Jolivalt, P Fernyhough - Current Drug Targets, 2008 - ingentaconnect.com
Abstract: There has been a rapid growth in appreciation of the diverse array of
neurotrophic factors, growth factors and other biological molecules that have
the capacity to support adult neurons and direct reparative processes after ...
Cited by 9 - Related articles - BL Direct - All 2 versions

Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate …


A Matsunaga, M Kawamoto, S Shiraishi, T … - European journal of pharmacology, 2007 - Elsevier
Members of the cyclooxygenase (COX) family are known to catalyze the
rate-limiting steps of prostaglandins synthesis and reported to be involved in
neuropathic pain. Diabetic neuropathy is a type of neuropathic pain, though ...
Cited by 17 - Related articles - All 5 versions

Impaired skin microvascular reactivity in painful diabetic neuropathy

- Free from Publisher
C Quattrini, ND Harris, RA Malik, S Tesfaye - Diabetes care, 2007 - Am Diabetes Assoc
RESULTS—In PDN, there were significantly reduced responses to Ach (ANOVA P =
0.003) and vasoconstrictor inspiratory gasp (ANOVA P < 0.001) but not to SNP
(NS). Post hoc analysis showed significant differences in Ach-induced ...
Cited by 10 - Related articles - BL Direct - All 5 versions

Novel sites of aldose reductase immunolocalization in normal and streptozotocin-diabetic …


Y Jiang, NA Calcutt, KM Ramos, AP Mizisin - J Peripher Nerv Syst, 2006 - interscience.wiley.com
Abstract Glucose metabolism by aldose reductase (AR) is implicated in the
pathogenesis of many diabetic complications, including neuropathy. We have
re-evaluated the distribution of AR in the sciatic nerve and dorsal root ...
Cited by 5 - Related articles - BL Direct - All 3 versions

Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of …

- pbrc.edu [PDF] 
I Vareniuk, IA Pavlov, IG Obrosova - Diabetologia, 2008 - Springer
Abstract Aims/hypothesis Evidence for the importance of peroxyni- trite, a
product of superoxide anion radical reaction with nitric oxide, in peripheral
diabetic neuropathy is emerging. The role of specific nitric oxide synthase ...
Cited by 4 - Related articles - All 5 versions


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