- ►diabetesjournals.org S Glund, A Deshmukh, YC Long, T Moller, HA … - Diabetes, 2007 - Am Diabetes Assoc Interleukin (IL)-6 is a proinflammatory cytokine shown to modify insulin sensitivity. Elevated plasma
levels of IL-6 are observed in insulin-resistant states. Interestingly, plasma IL-6 levels also increase
during exercise, with skeletal muscle being the predominant source. Thus, IL-6 has also ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►endojournals.org L Al-Khalili, K Bouzakri, S Glund, F Lonnqvist, … - Molecular …, 2006 - Endocrine Soc We identified signaling pathways by which IL-6 regulates skeletal muscle differentiation and
metabolism. Primary human skeletal muscle cells were exposed to IL-6 (25 ng/ml either acutely
or for several days), and small interfering RNA gene silencing was applied to measure ... Cited by 49 - Related articles - BL Direct - All 6 versions
A Krook, K Institutet - Am Diabetes Assoc Received for publication 13 December 2006 and accepted in revised form 23 February
2007. ... Stephan Glund1, Atul Deshmukh1, Yun Chau Long1, Theodore Moller1, Heikki A
Koistinen4, Kenneth Caidahl3, Juleen R Zierath1 and Anna Krook1,2 1Department of ... Related articles
AL Carey, GR Steinberg, SL Macaulay, WG Thomas, … - Diabetes, 2006 - Am Diabetes Assoc Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding
the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusion increases
glucose disposal without affecting the complete suppression of endogenous glucose ... Cited by 99 - Related articles - BL Direct - All 6 versions
- ►physiology.org PC Geiger, C Hancock, DC Wright, DH … - American Journal of …, 2007 - Am Physiological Soc Exercise induces an increase in glucose transport in muscle. As the acute increase in glucose
transport reverses, it is replaced by an increase in insulin sensitivity. Interleukin-6 (IL-6) increases
with exercise and has been reported to activate AMP-activated protein kinase (AMPK). ... Cited by 12 - Related articles - BL Direct - All 4 versions
- ►physiology.org BK Pedersen, MA Febbraio, RA … - Journal of Applied …, 2007 - Am Physiological Soc Growing evidence links Type 2 diabetes to a state of low-grade chronic inflammation, and it has
been suggested that interleukin (IL)-6 promotes insulin resistance due to the observation that
plasma IL-6 is often elevated in patients with metabolic disease. However, it is now well ... Cited by 15 - Related articles - All 4 versions
- ►physiology.org C Keller, A Steensberg, AK Hansen, CP … - Journal of Applied …, 2005 - Am Physiological Soc The cytokine interleukin-6 (IL-6) exerts it actions via the IL-6 receptor (IL-6R) in conjunction with
the ubiquitously expressed gp130 receptor. IL-6 is tightly regulated in response to exercise, being
affected by factors such as exercise intensity and duration, as well as energy availability. ... Cited by 27 - Related articles - BL Direct - All 6 versions
- ►bkpgroup.dk [PDF] MA Febbraio, BK Pedersen - Exercise and sport sciences reviews, 2005 - journals.lww.com FEBBRAIO, MA, and BK PEDERSEN. Contraction-induced myokine production and release:
Is skeletal muscle an endocrine organ? Exerc. Sport Sci. Rev., Vol. 33, No. 3, pp. 114–119,
2005. The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, ... Cited by 60 - Related articles - BL Direct - All 5 versions
- ►jbc.org C Weigert, AM Hennige, R Lehmann, K Brodbeck, F … - Journal of Biological …, 2006 - ASBMB The exercise-induced interleukin (IL)-6 production and secretion within skeletal muscle fibers
has raised the question of a putative tissue-specific function of IL-6 in the energy metabolism
of the muscle during and after the exercise. In the present study, we followed the ... Cited by 37 - Related articles - BL Direct - All 6 versions
- ►endocrinology-journals.org AG Holmes, JL Mesa, BA Neill, J Chung, AL … - Journal of …, 2008 - Soc Endocrinology Chronic elevations in interleukin (IL)-6 have been associated with insulin resistance, but acute
IL-6 administration can enhance insulin sensitivity. Our aim was to exogenously administer
IL-6 to rats to elicit either chronic or repeated acute elevations in systemic IL-6. We ... Cited by 4 - Related articles - All 5 versions
