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Adipose Mitochondrial Biogenesis Is Suppressed in db/db and High-Fat Diet–Fed …

- diabetesjournals.org
JX Rong, Y Qiu, MK Hansen, L Zhu, V Zhang, M Xie, Y … - Diabetes, 2007 - Am Diabetes Assoc
The objective of this study was to further establish and confirm the relationship of adipose mitochondrial
biogenesis in diabetes/obesity and the effects of rosiglitazone (RSG), a peroxisome
proliferator–activated receptor (PPAR) γ agonist, by systematically analyzing ...
Cited by 19 - Related articles - BL Direct - All 5 versions

Author Affiliation


JX Rong, Y Qiu, MK Hansen, L Zhu, V Zhang, M Xie, Y … - Am Diabetes Assoc
Received for publication 14 August 2006 and accepted in revised form 11 April 2007. ... Additional
information for this article can be viewed in an online appendix at http://diabetes.diabetesjournals
.org. ... James X Rong*,#, Yang Qiu†,‡, Michael K Hansen‡, Lei Zhu§,‡, Vivian Zhang‡, ...
Related articles

Time course of high-fat diet-induced reductions in adipose tissue mitochondrial …

- physiology.org
… , LC Capozzi, NJ Turchinsky, RC Bell, DC … - American Journal of …, 2008 - Am Physiological Soc
Increasing evidence suggests that reduced adipose tissue mitochondrial content is associated
with the pathogenesis of type 2 diabetes. These investigations have utilized severely
insulin-resistant rodent models. Thus, it is difficult to ascertain the potential mechanisms ...
Cited by 7 - Related articles - All 3 versions

Metabolic remodeling in adipocytes promotes ciliary neurotrophic factor-mediated …

- endojournals.org
S Crowe, SM Turpin, F Ke, BE Kemp, MJ Watt - Endocrinology, 2008 - Endocrine Soc
Obesity is characterized by an expanded adipose tissue mass, and reversing obesity reduces
the risk of insulin resistance and cardiovascular disease. Ciliary neurotrophic factor (CNTF) reverses
obesity by promoting the preferential loss of white adipose tissue. We evaluated the ...
Cited by 8 - Related articles - BL Direct - All 4 versions

Exercise and adrenaline increase PGC-1α mRNA expression in rat adipose tissue


LN Sutherland, MR Bomhof, LC Capozzi, … - The Journal of …, 2009 - Physiological Soc
The purpose of the present investigation was to explore the effects of exercise and adrenaline
on the mRNA expression of PGC-1α, a master regulator of mitochondrial biogenesis, in rat abdominal
adipose tissue. We hypothesized that (1) exercise training would increase PGC-1α mRNA ...
Cited by 1 - Related articles - All 4 versions

[CITATION] The effect of nicotinamide on the enzymatic activity of the antioxidant defense in …


MM Velykyi, VA Burda, NV Biront, OD Oliiarnyk, AM … - Ukr Biokhim Zh, 1996
Cited by 3 - Related articles

Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced …


D Pomplun, A Voigt, TJ Schulz, R … - Proceedings of the …, 2007 - National Acad Sciences
Published evidence suggests that adiposity in humans may be linked to impaired energy expenditure
for reasons widely unresolved. We have generated mice with a systemic impairment of oxidative
phosphorylation (OXPHOS) due to aP2 cre-mediated targeted disruption, and ...
Cited by 3 - Related articles - BL Direct - All 8 versions

Structural and functional consequences of mitochondrial biogenesis in human …

- endojournals.org
I Bogacka, B Ukropcova, M McNeil, JM Gimble, … - Journal of Clinical …, 2005 - Endocrine Soc
Results: The treatment of adipocytes with forskolin increased mitochondrial copy number and
the expression of genes involved in mitochondrial biogenesis (PPAR coactivator 1 and transcriptional
factor A) and fatty acid oxidation (PPAR and medium-chain acyl-coenzyme A ...
Cited by 52 - Related articles - BL Direct - All 5 versions

Essential role of mitochondrial function in adiponectin synthesis in adipocytes


EH Koh, JY Park, HS Park, MJ Jeon, JW Ryu, M Kim, … - Diabetes, 2007 - Am Diabetes Assoc
RESULTS—Adiponectin expression and mitochondrial content in adipose tissue were reduced
in obese db/db mice, and these changes were reversed by the administration of
rosiglitazone. In cultured adipocytes, induction of increased mitochondrial biogenesis (via ...
Cited by 16 - Related articles - BL Direct - All 4 versions

Comparison of the antidiabetic effects of brain-derived neurotrophic factor and …


M Yamanaka, Y Itakura, A Tsuchida, T … - Diabetes Obes …, 2007 - interscience.wiley.com
Aims: Brain-derived neurotrophic factor (BDNF) ameliorates glucose metabolism in obese diabetic
db/db mice. The antidiabetic effect of BDNF is dependent on plasma insulin levels, and BDNF
enhances insulin action by modulating insulin signalling in peripheral tissues. The aim of ...
Cited by 4 - Related articles - All 3 versions


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