J Pi, Y Bai, Q Zhang, V Wong, LM Floering, K Daniel, … - Diabetes, 2007 - Am Diabetes Assoc One of the unique features of β-cells is their relatively low expression of many antioxidant
enzymes. This could render β-cells susceptible to oxidative damage but may also provide a system
that is sensitive to reactive oxygen species as signals. In isolated mouse islets and INS-1( ... Cited by 35 - Related articles - BL Direct - All 6 versions
D Morgan, HR Oliveira-Emilio, D Keane, AE Hirata, M … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Acute or chronic exposure of beta cells to glucose, palmitic acid or
pro-inflammatory cytokines will result in increased production of the p47 phox component of
the NADPH oxidase and subsequent production of reactive oxygen species (ROS). ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org C Leloup, C Tourrel-Cuzin, C Magnan, M Karaca, J … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Transient glucose increase from 5.5 to 16.7 mmol/l stimulated ROS generation, which
was reversed by antioxidants. Insulin secretion was dose dependently blunted by antioxidants
and highly correlated with ROS levels. The incapacity of β-cells to secrete insulin in ... Cited by 7 - Related articles - All 4 versions
Y Uchizono, R Takeya, M Iwase, N Sasaki, M Oku, H … - Life Sciences, 2006 - Elsevier Increased oxidative stress plays a role in the pathogenesis of β-cell dysfunction and death. We
studied isoforms of NADPH oxidase components in islets of Langerhans isolated from rat pancreas
and tumoral rat β-cell line RINm5F cells by RT-PCR and sequencing of its products. ... Cited by 14 - Related articles - All 3 versions
- ►jbc.org P Maechler, L Jornot, CB Wollheim - Journal of Biological Chemistry, 1999 - ASBMB The effects of a transient exposure to hydrogen peroxide (10 min at 200 µM H 2 O 2 ) on pancreatic
beta cell signal transduction and insulin secretion have been evaluated. In rat islets, insulin secretion
evoked by glucose (16.7 mM) or by the mitochondrial substrate methyl succinate (5 mM) ... Cited by 118 - Related articles - BL Direct - All 6 versions
N Produit-Zengaffinen, N Davis-Lameloise, H Perreten, … - Diabetologia, 2007 - Springer Page 1. ARTICLE Increasing uncoupling protein-2 in pancreatic beta cells does not alter
glucose-induced insulin secretion but decreases production of reactive oxygen species N.
Produit-Zengaffinen & N. Davis-Lameloise & H. Perreten & D. Bécard & A. Gjinovci & PA Keller ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►endojournals.org H Imoto, N Sasaki, M Iwase, U Nakamura, M Oku, K … - Endocrinology, 2008 - Endocrine Soc Pancreatic islets express the superoxide-producing nicotinamide adenine dinucleotide phosphate
(NADPH) oxidase system, but its role remains unknown. To address this, we studied the mechanisms
of impaired insulin secretion induced by diphenyleneiodium (DPI), an NADPH oxidase ... Cited by 3 - Related articles - All 3 versions
N Li, F Frigerio, P Maechler - Biochemical Society Transactions, 2008 - biochemsoctrans.org Pancreatic β-cells are essential for the maintenance of glucose homoeostasis, and dysfunction
of these insulin-secreting cells results in the development of diabetes. In the course of events
leading from obesity to Type 2 diabetes, several mechanisms are currently envisaged. ... Cited by 3 - Related articles - Cached - All 4 versions
VP Bindokas, A Kuznetsov, S Sreenan, KS … - Journal of Biological …, 2003 - ASBMB Oxygen free radicals have been implicated in β-cell dysfunction and apoptosis associated with
type 1 and type 2 diabetes mellitus. The roles of free radicals in diabetes have thus far been
defined indirectly by monitoring oxidative tissue damage and the effects of antioxidants, ... Cited by 73 - Related articles - BL Direct - All 4 versions
P Maechler, PBM de Andrade - Biochemical Society Transactions, 2006 - maechler.unige.ch Abstract Pancreatic β-cells are able to respond to nutrients, principally glucose, as the primary
stimulus for insulin exocytosis. This unique feature requires translation of metabolic substrates
into intracellular messengers recognized by the exocytotic machinery. Central to this ... Cited by 13 - Related articles - View as HTML - BL Direct - All 7 versions
