LC Alonso, T Yokoe, P Zhang, DK Scott, SK … - Diabetes, 2007 - Am Diabetes Assoc Developing new techniques to induce β-cells to replicate is a major goal in
diabetes research. Endogenous β-cells replicate in response to metabolic
changes, such as obesity and pregnancy, which increase insulin requirement. ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►shouxi.net LC Alonso, T Yokoe, P Zhang, DK Scott, SK … - Diabetes, 2007 - Am Diabetes Assoc Page 1. Original Article Glucose Infusion in Mice A New Model to Induce
-Cell Replication Laura C. Alonso, 1 Takuya Yokoe, 2 Pili ... Related articles - All 2 versions
M Paris, C Bernard-Kargar, MF Berthault, L … - Endocrinology, 2003 - Endocrine Soc We investigated the specific and associated effects of insulin and glucose on
ß-cell growth and function in adult rats. By combining simultaneous infusion
either of glucose and/or insulin or glucose and diazoxide, three groups of ... Cited by 63 - Related articles - BL Direct - All 6 versions
- ►nih.gov Y Terauchi, I Takamoto, N Kubota, J Matsui, … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig 1 Department of Metabolic Diseases, Graduate School of Medicine, University of
Tokyo, Tokyo, Japan. 2 Core Research for Evolutional Science and Technology
(CREST), Japan Science and Technology Corporation (JST), Saitama, Japan. 3 ... Cited by 58 - Related articles - BL Direct - All 8 versions
BG Topp, MD McArthur, DT Finegood - Diabetologia, 2004 - Springer Aims/hypothesis. Several studies have employed the chronic glucose infusion
protocol to quantify the met- abolic adaptations associated with a prolonged
glu- cose challenge. However, the limited number of in- dices and time ... Cited by 36 - Related articles - BL Direct - All 5 versions
JJ Meier, AE Butler, Y Saisho, T Monchamp, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Little is known about the capacity, mechanisms, or timing of growth
in β-cell mass in humans. We sought to establish if the predominant expansion
of β-cell mass in humans occurs in early childhood and if, as in rodents, ... Cited by 23 - Related articles - All 3 versions
JJ Heit, SK Karnik, SK Kim, 2006 - Annual Reviews Abstract Once thought incapable of significant proliferation, the pancreatic
β-cell has recently been shown to harbor immense powers of self-renewal.
Pancreatic β-cells, the sole source of insulin in vertebrate animals, can ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►physiology.org TL Jetton, B Everill, J Lausier, V Roskens, A … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc The physiological mechanisms underlying pancreatic β-cell mass (BCM)
homeostasis are complex and not fully resolved. Here we examined the factors
contributing to the increased BCM following a mild glucose infusion (GI) ... Cited by 7 - Related articles - BL Direct - All 3 versions
MK Lingohr, I Briaud, LM Dickson, JF … - Journal of Biological Chemistry, 2006 - ASBMB Insulin receptor substrate 2 (IRS-2) plays a critical role in pancreatic
β-cells. Increased IRS-2 expression promotes β-cell growth and survival,
whereas decreased IRS-2 levels lead to apoptosis. It was found that IRS-2 ... Cited by 22 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org RC Vasavada, I Cozar-Castellano, D Sipula, … - Diabetes, 2007 - Am Diabetes Assoc Animal studies show that G 1/S regulatory molecules (D-cyclins, cdk-4, p18, p21,
p27) are critical for normal regulation of β-cell proliferation, mass, and
function. The retinoblastoma protein, pRb, is positioned at the very end of ... Cited by 12 - Related articles - BL Direct - All 5 versions
