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Alzheimer-like changes in rat models of spontaneous diabetes

- diabetesjournals.org
Z Li, W Zhang, AAF Sima - Diabetes, 2007 - Am Diabetes Assoc
RESULTS—Neuronal loss occurred in both models, significantly more so in type 2
diabetic BBZDR/Wor rats compared with type 1 diabetic BB/Wor rats and was
associated with a ninefold increase of dystrophic neurites. APP, ...
Cited by 27 - Related articles - BL Direct - All 5 versions

Alzheimer-like Changes in Rat Models of Spontaneous Diabetes


AAF Sima, W Count - Am Diabetes Assoc
Page 1. Alzheimer-like Changes in Rat Models of Spontaneous Diabetes Received for
publication 6 February 2007 and accepted in revised form 12 April 2007. ...
Related articles

The role of impaired insulin/IGF action in primary diabetic encephalopathy


Z Li, W Zhang, AAF Sima - Brain research, 2005 - Elsevier
We have previously shown that hippocampal neuronal apoptosis accompanied by
impaired cognitive functions occurs in type 1 diabetic BB/Wor rats. To
differentiate the contribution by insulin deficiency vs. that by ...
Cited by 31 - Related articles - All 4 versions

The pathological interaction between diabetes and presymptomatic Alzheimer's disease


JR Burdo, Q Chen, NA Calcutt, D Schubert - Neurobiology of Aging, 2009 - Elsevier
Since diabetes is a risk factor for Alzheimer's disease (AD), we asked if there
is a functional interaction between high glucose and elevated beta amyloid
peptide (Aβ) in cultured brain microvascular endothelial cells and ...
Cited by 7 - Related articles - All 2 versions

C-peptide reverses nociceptive neuropathy in type 1 diabetes

- shouxi.net
H Kamiya, W Zhang, K Ekberg, J Wahren, … - Diabetes, 2006 - Am Diabetes Assoc
We examined the therapeutic effects of C-peptide on established nociceptive
neuropathy in type 1 diabetic BB/Wor rats. Nociceptive nerve function,
unmyelinated sural nerve fiber and dorsal root ganglion (DRG) cell ...
Cited by 19 - Related articles - BL Direct - All 5 versions

C-peptide improves neuropathy in type 1 diabetic BB/Wor-rats


W Zhang, H Kamiya, K Ekberg, J Wahren, … - Diabetes/Metabolism Reviews - interscience.wiley.com
It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ...
Cited by 12 - Related articles - BL Direct - All 3 versions

Intranasal insulin to improve memory function in humans


C Benedict, M Hallschmid, B Schultes, J Born … - Neuroendocrinology, 2007 - content.karger.com
Background: Compelling evidence indicates that central nervous insulin enhances
learning and memory and in particular benefits hippocampus-dependent (ie,
declarative) memory. Intranasal administration of insulin provides an ...
Cited by 15 - Related articles - BL Direct - All 6 versions

The effects of type 1 diabetes on cerebral white matter


K Weinger, AM Jacobson, G Musen, IK Lyoo, … - Diabetologia, 2008 - Springer
Page 1. ARTICLE The effects of type 1 diabetes on cerebral white matter K. Weinger
& AM Jacobson & G. Musen & IK Lyoo & CM Ryan & DC Jimerson & PF Renshaw ...
Cited by 13 - Related articles - BL Direct - All 2 versions

The effect of C-peptide on cognitive dysfunction and hippocampal apoptosis in type 1 …

- shouxi.net
AAF Sima, Z Li - Diabetes, 2005 - Am Diabetes Assoc
Primary diabetic encephalopathy is a recently recognized late complication of
diabetes resulting in a progressive decline in cognitive faculties. In the
spontaneously type 1 diabetic BB/Wor rat, we recently demonstrated that ...
Cited by 34 - Related articles - All 6 versions

Is C-peptide replacement the missing link for successful treatment of neurological …


AAF Sima, H Kamiya - Current Drug Targets, 2008 - ingentaconnect.com
Abstract: In this review we will describe the interaction between insulin and
C-peptide which enhances and attenuates in- sulin-signaling functions. We will
describe how replenishment of C-peptide prevents and reverses the early ...
Cited by 5 - Related articles - BL Direct - All 2 versions


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