SJ Lessard, DA Rivas, ZP Chen, A Bonen, MA … - Diabetes, 2007 - Am Diabetes Assoc Both pharmacological intervention (ie, thiazolidinediones [TZDs]) and lifestyle modification
(ie, exercise training) are clinically effective treatments for improving whole-body insulin
sensitivity. However, the mechanism(s) by which these therapies reverse lipid-induced ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►physiology.org MK Todd, MJ Watt, J Le, AL Hevener, LP … - American Journal of …, 2007 - Am Physiological Soc In the present investigation, we studied the effects of thiazolidinedione (TZD) treatment on
insulin-stimulated fatty acid (FA) and glucose kinetics in perfused muscle from high-fat (HF)-fed
rats. We tested the hypothesis that TZDs prevent FA-induced insulin resistance by ... Cited by 22 - Related articles - BL Direct - All 6 versions
- ►physiology.org BB Yaspelkis III, SJ Lessard, DW Reeder, … - American Journal of …, 2007 - Am Physiological Soc The aims of this investigation were 1) to determine whether endurance exercise training could
reverse impairments in insulin-stimulated compartmentalization and/or activation of aPKC / and
Akt2 in skeletal muscle from high-fat-fed rodents and 2) to assess whether the PPAR ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►endojournals.org SJ Lessard, SLL Giudice, W Lau, JJ Reid, N Turner, MA … - Endocrinology, 2004 - Endocrine Soc We hypothesized that improved glucose tolerance with rosiglitazone treatment would coincide
with decreased levels of im triacylglycerol (IMTG), diacylglycerol, and ceramide. Obese Zucker
rats were randomly divided into two experimental groups: control (n = 9) and rosiglitazone ... Cited by 29 - Related articles - BL Direct - All 5 versions
L Pickersgill, GJ Litherland, AS Greenberg, M … - Journal of Biological …, 2007 - ASBMB Elevated non-esterified fatty acids, triglyceride, diacylglycerol, and ceramide have all been associated
with insulin resistance in muscle. We set out to investigate the role of intramyocellular lipid metabolites
in the induction of insulin resistance in human primary myoblast cultures. Muscle cells ... Cited by 23 - Related articles - All 11 versions
- ►physiology.org AC Smith, KL Mullen, KA Junkin, J … - American Journal of …, 2007 - Am Physiological Soc Derangements in skeletal muscle fatty acid (FA) metabolism associated with insulin resistance
in obesity appear to involve decreased FA oxidation and increased accumulation of lipids such
as ceramides and diacylglycerol (DAG). We investigated potential lipid-related ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►csun.edu [PDF] MK Singh, AD Krisan, AM Crain, DE Collins, BB … - Metabolism, 2003 - Elsevier The aim of this investigation was to evaluate if leptin treatment enhances insulin-stimulated glucose
transport in normal (experimental group [EXP]-1) and insulin-resistant skeletal muscle
(EXP-2) by altering components of the insulin-signaling cascade and/or glucose transport ... Cited by 25 - Related articles - All 9 versions
- ►physiology.org SJ Lessard, ZP Chen, MJ Watt, M Hashem … - American Journal of …, 2006 - Am Physiological Soc Rosiglitazone (RSG) is an insulin-sensitizing thiazolidinedione (TZD) that exerts peroxisome
proliferator-activated receptor- (PPAR )-dependent and -independent effects. We tested the hypothesis
that part of the insulin-sensitizing effect of RSG is mediated through the action of AMP- ... Cited by 26 - Related articles - BL Direct - All 4 versions
[CITATION] High fat feeding effects on components of the novel insulin signaling cascade in …
HJ Herr, JR Bernard, DW Reeder, DA Rivas, … - The Journal of …, 2005 - journal.shouxi.net Several recent reports using cell lines have suggested that both Akt and atypical protein kinase
C (aPKC) / are translocated to the plasma membrane (PM) in response to insulin. However, it
has yet to be determined in skeletal muscle whether: (1) insulin increases PM-associated ... Cited by 2 - Related articles - Cached - All 2 versions
