DML Tsukumo, MA Carvalho-Filho, JBC Carvalheira, … - Diabetes, 2007 - Am Diabetes Assoc Obesity is associated with insulin resistance and a state of abnormal inflammatory response.
The Toll-like receptor (TLR)4 has an important role in inflammation and immunity, and its expression
has been reported in most tissues of the body, including the insulin-sensitive ones. ... Cited by 101 - Related articles - BL Direct - All 7 versions
M Poggi, D Bastelica, P Gual, MA Iglesias, T Gremeaux … - Diabetologia, 2007 - Springer Page 1. ARTICLE C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected
against the development of insulin resistance in white adipose tissue in response to
a high-fat diet M. Poggi & D. Bastelica & P. Gual & MA Iglesias & ... Cited by 42 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org [PDF] F Kim, M Pham, I Luttrell, DD Bannerman, J … - Circulation …, 2007 - Am Heart Assoc Kluwer Health, 351 West Camden Street, Baltimore, MD 21202-2436. Phone:
410-528-4050. Permissions: Permissions & Rights Desk, Lippincott Williams & Wilkins, a division
of Wolters ... Toll Like Receptor-4 Mediates Vascular Inflammation and Cited by 81 - Related articles - All 16 versions
- ►nih.gov H Shi, MV Kokoeva, K Inouye, I Tzameli, H … - Journal of Clinical …, 2006 - Am Soc Clin Investig TLR4 is the receptor for LPS and plays a critical role in innate immunity. Stimulation of TLR4
activates proinflammatory pathways and induces cytokine expression in a variety of cell
types. Inflammatory pathways are activated in tissues of obese animals and humans and ... Cited by 320 - Related articles - BL Direct - All 13 versions
MJ Song, KH Kim, JM Yoon, JB Kim - Biochemical and biophysical research …, 2006 - Elsevier Chronic inflammation is closely associated with metabolic disorders such as obesity and type
2 diabetes, however, the underlying mechanism is unclear. Toll-like receptors (TLRs) play a
key role in innate immune response as well as inflammatory signals. Here, we observed ... Cited by 78 - Related articles - All 7 versions
T Suganami, T Mieda, M Itoh, Y Shimoda, Y Kamei, … - … and biophysical research …, 2007 - Elsevier Obese adipose tissue is characterized by increased infiltration of macrophages, suggesting that
they might represent an important source of inflammation. We have provided in vitro evidence
that saturated fatty acids, which are released from hypertrophied adipocytes via the ... Cited by 39 - Related articles - All 6 versions
- ►ahajournals.org T Suganami, K Tanimoto-Koyama, J Nishida, … - … , and vascular biology, 2007 - Am Heart Assoc From the Department of Molecular Medicine and Metabolism (TS, KT-K., JN, MI, XY, YK, YO)
and the Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstitution
of Tooth and Bone (YO), Medical Research Institute, Tokyo Medical and Dental ... Cited by 96 - Related articles - All 9 versions
- ►jneurosci.org M Milanski, G Degasperi, A Coope, J Morari, R … - Journal of …, 2009 - Soc Neuroscience In animal models of diet-induced obesity, the activation of an inflammatory response in the hypothalamus
produces molecular and functional resistance to the anorexigenic hormones insulin and
leptin. The primary events triggered by dietary fats that ultimately lead to hypothalamic ... Cited by 16 - Related articles - All 4 versions
JE Davis, NK Gabler, J Walker-Daniels, ME Spurlock - Obesity, 2008 - nature.com Toll-like receptor-4 (Tlr-4), a key pattern recognition receptor involved in innate immune
response, is activated by saturated fatty acids (SFAs). To investigate the involvement of this receptor
in obesity caused by consumption of diets high in fat, we utilized male Tlr-4-deficient ... Cited by 15 - Related articles - All 3 versions
- ►jbc.org MT Nguyen, S Favelyukis, AK Nguyen, D Reichart, … - Journal of Biological …, 2007 - ASBMB Obesity and type 2 diabetes are characterized by decreased insulin sensitivity, elevated concentrations
of free fatty acids (FFAs), and increased macrophage infiltration in adipose tissue (AT). Here,
we show that FFAs can cause activation of RAW264.7 cells primarily via the JNK ... Cited by 47 - Related articles - All 4 versions
