- ►shouxi.net C Huang, C Lin, L Haataja, T Gurlo, AE Butler, RA … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Endoplasmic reticulum (ER) stress–induced apoptosis may be a common cause
of cell attrition in diseases characterized by misfolding and oligomerisation of amyloidogenic
proteins. The islet in type 2 diabetes is characterized by islet amyloid derived from islet ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►pubget.com [PDF] DR Laybutt, AM Preston, MC Åkerfeldt, JG Kench, AK … - Diabetologia, 2007 - Springer Page 1. ARTICLE Endoplasmic reticulum stress contributes to beta cell apoptosis
in type 2 diabetes DR Laybutt & AM Preston & MC Åkerfeldt & JG Kench & AK Busch
& AV Biankin & TJ Biden Received: 21 September 2006 ... Cited by 105 - Related articles - BL Direct - All 5 versions
P Marchetti, M Bugliani, R Lupi, L Marselli, M Masini, U … - Diabetologia, 2007 - Springer Page 1. ARTICLE The endoplasmic reticulum in pancreatic beta cells of type 2
diabetes patients P. Marchetti & M. Bugliani & R. Lupi & L. Marselli & M. Masini &
U. Boggi & F. Filipponi & GC Weir & DL Eizirik & M. Cnop Received ... Cited by 47 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org CY Lin, T Gurlo, R Kayed, AE Butler, L Haataja, CG … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Islets in type 2 diabetes are characterized by a deficit in β-cells, increased β-cell
apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). The toxic form of amyloidogenic
protein oligomers are distinct and smaller than amyloid fibrils and act by disrupting ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell …, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss
in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the
molecular mechanisms implicated in FFA-induced ER stress initiation and apoptosis in ... Cited by 23 - Related articles - All 5 versions
H Elouil, M Bensellam, Y Guiot, D Vander Mierde, SMA … - Diabetologia, 2007 - Springer Page 1. ARTICLE Acute nutrient regulation of the unfolded protein response and
integrated stress response in cultured rat pancreatic islets H. Elouil & M. Bensellam
& Y. Guiot & D. Vander Mierde & SMA Pascal & FC Schuit & JC Jonas ... Cited by 18 - Related articles - BL Direct - All 6 versions
- ►jbc.org M Cnop, L Ladriere, P Hekerman, F Ortis, AK … - Journal of Biological …, 2007 - ASBMB Free fatty acids cause pancreatic -cell apoptosis and may contribute to -cell loss in type 2 diabetes
via the induction of endoplasmic reticulum stress. Reductions in eukaryotic translation initiation
factor (eIF) 2 phosphorylation trigger -cell failure and diabetes. Salubrinal selectively ... Cited by 44 - Related articles - All 6 versions
- ►diabetesjournals.org AV Matveyenko, PC Butler - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by defects in insulin secretion and action and is preceded by
impaired fasting glucose (IFG). The islet anatomy in IFG and type 2 diabetes reveals an ∼50
and 65% deficit in β-cell mass, with increased β-cell apoptosis and islet amyloid derived ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org P Pirot, F Ortis, M Cnop, Y Ma, LM Hendershot, DL … - Diabetes, 2007 - Am Diabetes Assoc Endoplasmic reticulum stress–mediated apoptosis may play an important role in the destruction
of pancreatic β-cells, thus contributing to the development of type 1 and type 2 diabetes. One
of the regulators of endoplasmic reticulum stress–mediated cell death is the CCAAT/ ... Cited by 23 - Related articles - BL Direct - All 8 versions
- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
