N Turner, CR Bruce, SM Beale, KL Hoehn, T So, MS … - Diabetes, 2007 - Am Diabetes Assoc A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has been proposed
as a major factor leading to the accumulation of intramuscular lipids and their subsequent deleterious
effects on insulin action. Here, we examine markers of mitochondrial fatty acid oxidative ... Cited by 63 - Related articles - BL Direct - All 5 versions
- ►pnas.org CR Hancock, DH Han, M Chen, S Terada … - Proceedings of the …, 2008 - National Acad Sciences It has been hypothesized that insulin resistance is mediated by a deficiency of mitochondria in
skeletal muscle. In keeping with this hypothesis, high-fat diets that cause insulin resistance have
been reported to result in a decrease in muscle mitochondria. In contrast, we found that ... Cited by 42 - Related articles - BL Direct - All 8 versions
N Turner, CR Bruce, SM Beale, KL Hoehn, T So, MS … - DIABETES, 2007 - Am Diabetes Assoc A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has been proposed
as a major factor leading to the accumulation of intramuscular lipids and their subsequent deleterious
effects on insulin action. Here, we examine markers of mitochondrial fatty acid oxidative ... Related articles - All 2 versions
- ►pnas.org P Garcia-Roves, JM Huss, DH Han, CR … - Proceedings of the …, 2007 - National Acad Sciences A number of studies have reported that a high-fat diet induces increases in mitochondrial fatty
acid oxidation enzymes in muscle. In contrast, in two recent studies raising plasma free fatty acids
(FFA) resulted in a decrease in mitochondria. In this work, we reevaluated the effects of ... Cited by 36 - Related articles - BL Direct - All 8 versions
C Bonnard, A Durand, S Peyrol, E … - The Journal of …, 2008 - pubmedcentral.nih.gov Mitochondrial dysfunction in skeletal muscle has been implicated in the development of type
2 diabetes. However, whether these changes are a cause or a consequence of insulin resistance
is not clear. We investigated the structure and function of muscle mitochondria during the ... Cited by 53 - Related articles - BL Direct - All 8 versions
- ►cell.com TR Koves, JR Ussher, RC Noland, D Slentz, M … - Cell metabolism, 2008 - Elsevier Previous studies have suggested that insulin resistance develops secondary to diminished fat
oxidation and resultant accumulation of cytosolic lipid molecules that impair insulin
signaling. Contrary to this model, the present study used targeted metabolomics to find ... Cited by 120 - Related articles - All 9 versions
- ►physiology.org … A Thrush, GJF Heigenhauser, NN Tandon … - American Journal of …, 2007 - Am Physiological Soc A reduction in fatty acid oxidation has been associated with lipid accumulation and insulin resistance
in the skeletal muscle of obese individuals. We examined whether this decrease in fatty acid
oxidation was attributable to a reduction in muscle mitochondrial content and/or a ... Cited by 23 - Related articles - BL Direct - All 7 versions
- ►nih.gov R Boushel, E Gnaiger, P Schjerling, M Skovbro, R … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Insulin resistance and type 2 diabetes are associated with mitochondrial
dysfunction. The aim of the present study was to test the hypothesis that oxidative phosphorylation
and electron transport capacity are dimin- ished in the skeletal muscle of type 2 diabetic ... Cited by 80 - Related articles - BL Direct - All 9 versions
M Mogensen, K Sahlin, M Fernström, D Glintborg, BF … - Diabetes, 2007 - Am Diabetes Assoc We tested the hypothesis of a lower respiratory capacity per mitochondrion in skeletal muscle
of type 2 diabetic patients compared with obese subjects. Muscle biopsies obtained from 10
obese type 2 diabetic and 8 obese nondiabetic male subjects were used for assessment ... Cited by 50 - Related articles - BL Direct - All 6 versions
