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Scholar Results 1 - 10 of about 101 related to Ishikawa: Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody. (0.10 sec) 

Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal …

- shouxi.net
H Ishikawa, H Ochi, ML Chen, D Frenkel, R Maron, HL … - Diabetes, 2007 - Am Diabetes Assoc
Anti-CD3 monoclonal antibody (mAb) has been shown to induce tolerance and to be an effective
treatment for diabetes both in animal models and in human trials. We have shown that anti-CD3
mAb given orally is biologically active in the gut and suppresses experimental ...
Cited by 17 - Related articles - BL Direct - All 5 versions

[PDF] Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by …


H Ochi, M Abraham, H Ishikawa, D Frenkel, K Yang, AS … - Nat Med, 2006 - 140.116.93.232
A major goal of immunotherapy for autoimmune diseases and transplantation is induction of
regulatory T cells that mediate immunologic tolerance. The mucosal immune system is
unique, as tolerance is preferentially induced after exposure to antigen, and induction of ...
Cited by 58 - Related articles - View as HTML - BL Direct - All 9 versions

Induction of oral immune regulation towards liver-extracted proteins for treatment of …


E Israeli, R Safadi, A Melhem, O Pappo, O … - Liver …, 2004 - interscience.wiley.com
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Cited by 12 - Related articles - BL Direct - All 3 versions

Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ …

- jimmunol.org
HY Wu, FJ Quintana, HL Weiner - The Journal of Immunology, 2008 - Am Assoc Immnol
Lupus is an Ab-mediated autoimmune disease. One of the potential contributors to the development
of systemic lupus erythematosus is a defect in naturally occurring CD4 + CD25 + regulatory T
cells. Thus, the generation of inducible regulatory T cells that can control autoantibody ...
Cited by 9 - Related articles - All 4 versions

Oral immune regulation toward disease-associated antigens: results of Phase I …


Y Ilan - Ann NY Acad Sci, 2004 - interscience.wiley.com
Abstract: Oral immune regulation is an immune response toward orally administered
antigens, and is a balance between several types of responses. Recent studies in animal models
have shown that antiviral immunity and the immune response toward colonic proteins can ...
Cited by 6 - Related articles - All 6 versions

A double-blind clinical trial for treatment of Crohn's disease by oral administration …


M Margalit, E Israeli, O Shibolet, E … - American Journal of …, 2006 - interscience.wiley.com
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Cited by 16 - Related articles - BL Direct - All 6 versions

In vitro induction of regulatory T cells by anti-CD3 antibody in humans


M Abraham, A Karni, A Dembinsky, A Miller, R Gandhi, … - Journal of autoimmunity, 2008 - Elsevier
Therapy with anti-CD3 antibody is effective in controlling models of autoimmune diseases and
can reverse or prevent rejection of grafts. We studied the in vitro immunomodulatory effect of
anti-CD3 treated human T cells. CD4 + T cells were stimulated with plate-bound anti-CD3 ...
Cited by 21 - Related articles - All 4 versions

Is oral tolerance correlated with IgE levels and mast cell numbers?


AC DA SILVA, MFS SILVA, C BIANCHI, … - Annals of the New …, 2004 - interscience.wiley.com
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Oral immune regulation: a new mode of therapy against chronic viral infections


L Levy, Y Ilan - Recent Patents on Anti-Infective Drug Discovery, 2007 - ingentaconnect.com
Received: September 2, 2007; Accepted: September 26, 2007; Revised: September 27, 2007
Abstract: Oral tolerance is a method to alter the immune response towards orally administered
antigens. The use of oral tolerance as a method of therapy for various immune mediated ...
Cited by 3 - Related articles - BL Direct - All 2 versions

Remission and pancreas isograft survival in recent onset diabetic NOD mice after …


PL Mottram, LJ Murray-Segal, W Han, J Maguire, AN … - Transplant Immunology, 2002 - Elsevier
Diabetes in NOD mice is an autoimmune disease similar to Type I diabetes in humans. Prior
to hypoglycemia, changes in the islet infiltrate led to autoreactive T cell activation and destruction
of the insulin-producing β cells. If T cell activation can be inhibited before β cell ...
Cited by 13 - Related articles - All 4 versions


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