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Surrogate markers of small fiber damage in human diabetic neuropathy


C Quattrini, M Tavakoli, M Jeziorska, P Kallinikos, S … - Diabetes, 2007 - Am Diabetes Assoc
Surrogate markers of diabetic neuropathy are being actively sought to facilitate the
diagnosis, measure the progression, and assess the benefits of therapeutic intervention in patients
with diabetic neuropathy. We have quantified small nerve fiber pathological changes ...
Cited by 34 - Related articles - BL Direct - All 6 versions

Surrogate Markers of Small Fiber Damage in Human Diabetic Neuropathy.


UK Manchester, UK Manchester - Am Diabetes Assoc
Received for publication 28 February 2007 and accepted in revised form 12 May 2007. ... Cristian
Quattrini1, Mitra Tavakoli1, Maria Jeziorska2, Panagiotis Kallinikos1, Solomon Tesfaye3, Joanne
Finnigan4, Andrew Marshall4, Andrew JM Boulton1, Nathan Efron5, Rayaz A Malik1.
Related articles

Corneal confocal microscopy detects early nerve regeneration after pancreas …


S Mehra, M Tavakoli, PA Kallinikos, N Efron, AJM … - Diabetes Care, 2007 - Am Diabetes Assoc
RESULTS—Corneal sensitivity (1.54 ± 0.28 vs. 0.77 ± 0.02, P < 0.0001), nerve fiber density
(NFD) (13.8 ± 2.1 vs. 42 ± 3.2, P < 0.0001), nerve branch density (NBD) (4.04 ± 1.5 vs. 26.7 ±
2.5, P < 0.0001), and nerve fiber length (NFL) (2.23 ± 0.2 vs. 9.69 ± 0.7, P < 0.0001) were ...
Cited by 16 - Related articles - BL Direct - All 6 versions

Reduced vascular endothelial growth factor expression and intra-epidermal nerve …

- diabetesjournals.org
C Quattrini, M Jeziorska, AJM Boulton, RA Malik - Diabetes Care, 2008 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS—Fifty-three diabetic patients and 12 nondiabetic control
subjects underwent neurological evaluation, electrophysiology, quantitative sensory, and autonomic
function testing. Dermal blood flow responses were evaluated with laser Doppler ...
Cited by 11 - Related articles - BL Direct - All 4 versions

Severe depletion of intraepidermal nerve fibers in skin biopsies of pancreas …


P Boucek, T Havrdova, L Voska, A Lodererova, F … - Transplantation …, 2005 - Elsevier
Skin biopsies were performed using a 3-mm punch from lower thigh and upper calf areas of 16
(13 pancreas/kidney, 3 pancreas alone) PTx patients (mean ± SD: age, 45 ± 8 years; type 1 diabetes
duration, 27 ± 8 years) at 1 month posttransplant. Ten healthy gender- and age-matched ...
Cited by 11 - Related articles - All 6 versions

Lifestyle intervention for pre-diabetic neuropathy


AG Smith, J Russell, EL Feldman, J Goldstein, A … - Diabetes Care, 2006 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS—We performed 3-mm skin biopsies with measurement
of IENFD at the distal leg and proximal thigh at baseline and after 1 year in 32 subjects with
IGT. Each received individualized diet and exercise counseling as a standard of care. ...
Cited by 58 - Related articles - BL Direct - All 6 versions

Skin biopsy: a new tool for diagnosing peripheral neuropathy


G Lauria, R Lombardi - British Medical Journal, 2007 - bmj.com
The prevalence of peripheral neuropathy is about 2% in the general population, but it rises to
12% and 17% in people with one or two recognised risk factors. 1 Diabetes is one such risk factor
and the most common cause of this disorder—about half of patients who have had ...
Cited by 11 - Related articles - BL Direct - All 5 versions

The relationship among pain, sensory loss, and small nerve fibers in diabetes

- diabetesjournals.org
L Sorensen, L Molyneaux, DK Yue - Diabetes Care, 2006 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS—Twenty-five diabetic subjects with neuropathic pain
and 13 without were studied. The pain was present for at least 6 months for which no other cause
could be found. Punch skin biopsies were obtained from the distal leg. IENFs were ...
Cited by 37 - Related articles - BL Direct - All 5 versions

Characteristics of patients with sensory neuropathy diagnosed with abnormal small …

- nih.gov
EA De Sousa, AP Hays, RL Chin, HW Sander, TH … - British Medical …, 2006 - jnnp.bmj.com
ABSTRACT Clinical, laboratory and electrodiagnostic (EDX) characteristics of 62 patients with
sensory neuropathy with abnormal skin biopsies were reviewed. Reduced epidermal nerve fibre
density (ENFD) was seen in 71% and morphological changes with normal ENFD were ...
Cited by 15 - Related articles - BL Direct - All 6 versions

Pain and small-fiber neuropathy in patients with hypothyroidism


K Orstavik, I Norheim, E Jorum - Neurology, 2006 - AAN Enterprises
Results: Eighteen patients had ongoing or intermittent ongoing distal pain in their limbs. Of
these, 8 reported evoked and 10 reported paroxysmal pain. Fifteen patients had only diffuse
musculoskeletal pain. A total of 16 patients had "hyperphenomena" (brush-evoked ...
Cited by 13 - Related articles - BL Direct - All 3 versions


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