- ►diabetesjournals.org HI Callewaert, CA Gysemans, L Ladrière, W D'Hertog, J … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Exposure of β-cells to inflammatory cytokines leads to apoptotic cell death through
the activation of gene networks under the control of specific transcription factors, such as
interferon-γ–induced signal transducer and activator of transcription (STAT)-1. We ... Cited by 14 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org S Kim, HS Kim, KW Chung, SH Oh, JW Yun, SH Im, MK … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—STAT1 −/− islet cells were resistant to death by interferon (IFN)-γ/tumor necrosis
factor (TNF)-α or IFN-γ/interleukin (IL)-1β combination. Cytochrome c translocation by
IFN-γ/TNF-α was abrogated in STAT1 −/− islet cells. The induction of X-linked inhibitor of ... Cited by 8 - Related articles - BL Direct - All 6 versions
I Hanne, A Conny, WD Laurence Ladrière2 PhD, C … - Am Diabetes Assoc Hanne I. Callewaert1,☯ (MSc), Conny A. Gysemans1,☯ (PhD), Laurence Ladrière2 (PhD), Wannes
D' Hertog1 (MSc), Julianna Hagenbrock1 (BSc), Lutgart Overbergh1 (PhD), Decio L. Eizirik2
(MD, PhD) and Chantal Mathieu1 (MD, PhD). ... 1Laboratory of Experimental Medicine ... Related articles
D Eizirik, F Moore, D Flamez, F Ortis - Biochemical Society …, 2008 - biochemsoctrans.org Accumulating evidence indicates that β-cells die by apoptosis in T1DM (Type 1 diabetes
mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that
β-cell apoptosis depends on the parallel and/or sequential up- and down-regulation of ... Cited by 9 - Related articles - Cached - BL Direct - All 6 versions
CA Gysemans, L Ladrière, H Callewaert, J Rasschaert, … - Diabetes, 2005 - Am Diabetes Assoc The main focus in studies on the pathogenesis of autoimmune type 1 diabetes has been on the
role of the immune system, with much less attention directed to the target of the immune
assault, namely the insulin-secreting β-cells. β-Cells under inflammatory attack have ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org X Wang, S Jia, R Geoffrey, R Alemzadeh, S … - The Journal of …, 2008 - Am Assoc Immnol Understanding active proinflammatory mechanisms at and before type 1 diabetes mellitus
(T1DM) onset is hindered in humans, given that the relevant tissues are inaccessible and pancreatic
immune responses are difficult to measure in the periphery by traditional approaches. ... Cited by 11 - Related articles - All 2 versions
H Mori, T Shichita, Q Yu, R Yoshida, M Hashimoto, … - … and Biophysical Research …, 2007 - Elsevier Type 1 diabetes results from the selective destruction of insulin-producing pancreatic β-cells
during islet inflammation, which involves inflammatory cytokines and free radicals. However,
mechanisms for protecting β-cells from destruction have not been clarified. In this study, ... Cited by 7 - Related articles - All 5 versions
- ►uva.nl [PDF] TC Schreuder, HC Gelderblom, CJ Weegink, D … - Liver International, 2008 - medscape.com We screened for DM during and after treatment with pegylated-IFN-α (Peg-IFN-α) and Riba for
chronic HCV infection. This started after we observed two index cases of DM during
Peg-IFN-α/Riba treatment in our hospital in December 2002. In the first patient, ... Cited by 8 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org [PDF] Z Dogusan, M García, D Flamez, L Alexopoulou, M … - Diabetes, 2008 - Am Diabetes Assoc 1 Laboratory of Experimental Medicine, Université Libre de Bruxelles, Brussels, Belgium. 2 Centre
d'Immunologie de Marseille-Luminy, CNRS-INSERM- Université de la Mediterranée,
Marseille, France. 3 Institute of Medical Immunology, Université Libre de Bruxelles, ... Cited by 9 - Related articles - All 2 versions
