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Scholar Results 1 - 10 of about 101 related to Pearson: Variation in TCF7L2 influences therapeutic response to sulfonylureas. (0.11 sec) 

Variation in TCF7L2 influences therapeutic response to sulfonylureas

- diabetesjournals.org
ER Pearson, LA Donnelly, C Kimber, A Whitley, ASF … - Diabetes, 2007 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS— The DARTS/MEMO (Diabetes Audit and Research
Tayside/Medicines Monitoring Unit) collaboration database includes prescribing,
biochemistry, and clinical phenotype of all patients with diabetes within Tayside, ...
Cited by 45 - Related articles - BL Direct - All 5 versions

Variation in TCF7L2 influences therapeutic response to sulfonylureas: A GoDARTs …


B Whitley, ASFD PhD, MI McCarthy, AT Hattersley, AD … - Am Diabetes Assoc
Affiliations 1. Division of Medicine & Therapeutics, University of Dundee, UK. 2. Health Informatics
Centre, University of Dundee, UK. 3. Population Pharmacogenetics Group, Biomedical Research
Centre, University of Dundee, UK. 4. Oxford Centre for Diabetes, Endocrinology & ...
Related articles

Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with …


Y Feng, G Mao, X Ren, H Xing, G Tang, Q Li, X Li, L … - Diabetes Care, 2008 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS—A total of 1,268 type 2 diabetic patients whose diabetes
was diagnosed within the past 5 years and who had no recent hypoglycemic treatment were
enrolled from 23 hospitals in China. All of the patients were treated with gliclazide for 8 ...
Cited by 9 - Related articles - All 4 versions

The E23K Variant of KCNJ11 Encoding the Pancreatic {beta}-Cell Adenosine 5'- …

- endojournals.org
G Sesti, E Laratta, M Cardellini, F Andreozzi, S … - Journal of Clinical …, 2006 - Endocrine Soc
Context: Several studies suggest that genetic factors may play a role in the different responses
to antidiabetic therapy; however, conclusive evidence is still lacking. ... Objective: The objective
of the study was to investigate whether diabetic patients carrying the E23K variant in ...
Cited by 26 - Related articles - BL Direct - All 3 versions

The new type 2 diabetes gene TCF7L2

- utah.edu [PDF] 
JC Florez - Current Opinion in Clinical Nutrition & Metabolic Care, 2007 - journals.lww.com
Purpose of review Common variants in the gene that encodes the transcription factor 7-like 2
(TCF7L2) have been strongly associated with type 2 diabetes. This highly reproducible association
may uncover novel mechanisms of glycemic pathophysiology. Recent findings The initial ...
Cited by 36 - Related articles - BL Direct - All 4 versions

TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes …


CH Kimber, ASF Doney, ER Pearson, MI McCarthy, AT … - Diabetologia, 2007 - Springer
Abstract Aims/hypothesis The gene encoding transcription factor 7- like 2 (TCF7L2) has been
identified as a type 2 diabetes locus from genome-wide linkage studies and subsequent association
analysis. We investigated the role of two common variants in TCF7L2 in a large ...
Cited by 27 - Related articles - BL Direct - All 4 versions

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with …


K Kirchhoff, F Machicao, A Haupt, SA Schäfer, O … - Diabetologia, 2008 - Springer
Abstract Aims/hypothesis Variation within six novel genetic loci has been reported to confer risk
of type 2 diabetes and may be associated with beta cell dysfunction. We investigated whether
these polymorphisms are also associated with impaired proinsulin to insulin conversion. ...
Cited by 38 - Related articles - BL Direct - All 3 versions

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 …

- pubget.com [PDF] 
J Wang, J Kuusisto, M Vänttinen, T Kuulasmaa, J … - Diabetologia, 2007 - Springer
Page 1. ARTICLE Variants of transcription factor 7-like 2 (TCF7L2) gene predict
conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are
associated with impaired glucose regulation and impaired insulin secretion ...
Cited by 51 - Related articles - BL Direct - All 4 versions

TCF7L2 polymorphisms modulate proinsulin levels and β-cell function in a British …


RJF Loos, PW Franks, RW Francis, I Barroso, FM … - Diabetes, 2007 - Am Diabetes Assoc
Rapidly accumulating evidence shows that common T-cell transcription factor (TCF)7L2 polymorphisms
confer risk of type 2 diabetes through unknown mechanisms. We examined the association between
four TCF7L2 single nucleotide polymorphisms (SNPs), including rs7903146, and ...
Cited by 53 - Related articles - BL Direct - All 8 versions

Effective treatment with oral sulfonylureas in patients with diabetes due to …

- diabetesjournals.org
M Rafiq, SE Flanagan, AM Patch, BM Shields, S … - Diabetes Care, 2008 - Am Diabetes Assoc
OBJECTIVE—Neonatal diabetes can result from mutations in the Kir6.2 or sulfonylurea receptor
1 (SUR1) subunits of the ATP-sensitive K + channel. Transfer from insulin to oral sulfonylureas
in patients with neonatal diabetes due to Kir6.2 mutations is well described, but less is ...
Cited by 19 - Related articles - BL Direct - All 5 versions


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