- ►shouxi.net S Casas, R Gomis, FM Gribble, J Altirriba, S Knuutila, A … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Increased expression of several heat shock proteins and activation of the spliced
form of XBP-1, a transcription factor for overexpression of chaperones during endoplasmic reticulum
(ER) stress, were detected together with morphological evidence of ER dysfunction. ... Cited by 12 - Related articles - BL Direct - All 4 versions
S Casas, R Gomis, FM Gribble, J Altirriba, S Knuutila, A … - Diabetes, 2007 - Am Diabetes Assoc S. Casas 1,2, R. Gomis 1, FM Gribble 3, J. Altirriba 1, S. Knuutila 4, A. Novials 2,* 1 Endocrinology
and Diabetes Unit, Laboratory of Experimental Diabetes, IDIBAPS, Hospital Clinic and University
of Barcelona, Barcelona, Spain; 2 Institute of Diabetes, Sardà Farriol Foundation, ... Cited by 3 - Related articles - All 2 versions
HL Zhao, Y Sui, J Guan, L He, XM Gu, HK Wong, L … - Translational Research, 2009 - Elsevier The amyloid hypothesis of type 2 diabetes mellitus postulates that elevated levels of normally
expressed monomeric proteins of human islet amyloid polypeptide (hIAPP) trigger oligomerization
that independently causes fibril formation and disease progression. The aim of this study ... Cited by 1 - Related articles - All 12 versions
- ►physiology.org C Huang, L Haataja, T Gurlo, AE Butler, X … - American Journal of …, 2007 - Am Physiological Soc The islet in type 2 diabetes is characterized by an 60% β-cell deficit, increased β-cell
apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). Human IAPP
(hIAPP) but not rodent IAPP (rIAPP) forms toxic oligomers and amyloid fibrils in an ... Cited by 10 - Related articles - BL Direct - All 3 versions
S Casas, A Novials, F Reimann, R Gomis, FM Gribble - Diabetologia, 2008 - Springer Abstract Aims/hypothesis To investigate the mechanism by which human islet amyloid polypeptide
(hIAPP) fibril formation results in calcium influx across the plasma membrane of pancreatic beta
cells, and its association with apoptosis. Methods Cytoplasmic intracellular calcium ... Cited by 3 - Related articles - All 3 versions
- ►diabetesjournals.org S Zhang, H Liu, H Yu, GJS Cooper - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS— We measured responses to hA in isolated mouse islets
and two insulinoma cell lines, wherein we measured Fas/Fas ligand (FasL) and Fas-associated
death domain (FADD) expression by quantitative RT-PCR, Western blotting, and ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org CY Lin, T Gurlo, R Kayed, AE Butler, L Haataja, CG … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Islets in type 2 diabetes are characterized by a deficit in β-cells, increased β-cell
apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). The toxic form of amyloidogenic
protein oligomers are distinct and smaller than amyloid fibrils and act by disrupting ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►shouxi.net C Huang, C Lin, L Haataja, T Gurlo, AE Butler, RA … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Endoplasmic reticulum (ER) stress–induced apoptosis may be a common cause
of cell attrition in diseases characterized by misfolding and oligomerisation of amyloidogenic
proteins. The islet in type 2 diabetes is characterized by islet amyloid derived from islet ... Cited by 56 - Related articles - BL Direct - All 5 versions
L Rumora, M Hadzija, K Bariic, D Maysinger, … - Biological …, 2002 - reference-global.com Nanomolar concentrations of human amylin promote death of RINm5F cells in a time- and
concentration- dependent manner. Morphological changes of chro- matin integrity suggest that
cells are predominantly undergoing apoptosis. Human amylin induces signifi- cant ... Cited by 18 - Related articles - BL Direct - All 6 versions
- ►jbc.org M Kawaguchi, K Minami, K Nagashima, S Seino - Journal of Biological …, 2006 - ASBMB Insulin secretion from pancreatic -cells occurs by sequential cellular processes, including glucose
metabolism, electrical activity, Ca 2+ entry, and regulated exocytosis. Abnormalities in any of
these functions can impair insulin secretion. In the present study, we demonstrate that ... Cited by 8 - Related articles - BL Direct - All 6 versions
