- ►diabetesjournals.org M Hao, WS Head, SC Gunawardana, AH Hasty … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Type 2 diabetes is often accompanied by abnormal blood lipid and
lipoprotein levels, but most studies on the link between hyperlipidemia and
diabetes have focused on free fatty acids (FFAs). In this study, we ... Cited by 14 - Related articles - BL Direct - All 4 versions
LR Brunham, JK Kruit, CB Verchere, MR … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov Type 2 diabetes (T2D) frequently occurs in the context of abnormalities of
plasma lipoproteins. However, a role for elevated levels of plasma cholesterol
in the pathogenesis of this disease is not well established. Recent ... Cited by 11 - Related articles - BL Direct - All 6 versions
M Ishikawa, F Okajima, N Inoue, K Motomura … - Journal of atherosclerosis and thrombosis, 2006 - sinoas.com Statins are specific and potent competitive inhib- itors of
3-hydroxy-3methylglutaryl coenzyme A (HMG- CoA) reductase and are widely used as
plasma choles- terol-lowering drugs to prevent the development and ... Cited by 8 - Related articles - BL Direct - All 3 versions
LR Brunham, JK Kruit, TD Pape, JM Timmins, … - Nature medicine, 2007 - nature.com Type 2 diabetes is characterized by both peripheral insulin resistance and
reduced insulin secretion by -cells. The reasons for -cell dysfunction in this
disease are incompletely understood but may include the accumulation of ... Cited by 44 - Related articles - BL Direct - All 6 versions
MV Chakravarthy, CF Semenkovich - Nature medicine, 2007 - mcb.arizona.edu Entia non sunt multiplicanda praeter neces- sitatem—entities should not be
multiplied beyond necessity, or, the simplest solution is best. This dictum,
commonly attributed to the 14th century English philosopher William of ... Cited by 5 - Related articles - View as HTML - BL Direct - All 5 versions
- ►diabetesjournals.org T Kato, H Shimano, T Yamamoto, M Ishikawa, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Incubation of C57BL/6 islets with palmitate caused inhibition of both
glucose- and potassium-stimulated insulin secretion, but addition of
eicosapentaenoate (EPA) restored both inhibitions. Concomitantly, palmitate ... Cited by 11 - Related articles - All 6 versions
MT Villarreal-Molina, CA Aguilar-Salinas, M … - Diabetes, 2007 - Am Diabetes Assoc Short running title: ABCA1 gene variant is associated with obesity ... 1. Unit
of Molecular Biology and Genomic Medicine, Instituto Nacional de Ciencias
Médicas y Nutrición Salvador Zubirán (INCMNSZ), Instituto de ... Cited by 9 - Related articles
MT Villarreal-Molina, MT Flores-Dorantes, O … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—R230C/C230C genotypes were significantly more frequent in type 2
diabetic individuals (24.6%) than in control subjects (11.4%) in the initial
study group (OR 2.501; P = 0.001). After stratifying by age at diagnosis, ... Cited by 9 - Related articles - BL Direct - All 4 versions
H Shimano, M Amemiya-Kudo, A Takahashi, T … - Diabetes Obes Metab, 2007 - interscience.wiley.com It has long been known that excess intracellular fatty acids cause impaired
insulin secretion, referred to as β-cell lipotoxicity. Sterol regulatory
element–binding protein (SREBP)-1c is a transcription factor that ... Cited by 10 - Related articles - All 2 versions
- ►jbc.org M Amemiya-Kudo, J Oka, T Ide, T Matsuzaka, … - Journal of Biological Chemistry, 2005 - ASBMB Insulin gene expression is regulated by pancreatic cell-specific factors, PDX-1
and BETA2/E47. Here we have demonstrated that the insulin promoter is a novel
target for SREBPs established as lipid-synthetic transcription factors. ... Cited by 14 - Related articles - BL Direct - All 7 versions
