- ►diabetesjournals.org FF Yan, YW Lin, C MacMullen, A Ganguly, CA … - Diabetes, 2007 - Am Diabetes Assoc Congenital hyperinsulinism (CHI) is a disease characterized by persistent
insulin secretion despite severe hypoglycemia. Mutations in the pancreatic
ATP-sensitive K + (K ATP ) channel proteins sulfonylurea receptor 1 (SUR1) ... Cited by 8 - Related articles - BL Direct - All 5 versions
FF Yan, YW Lin, C MacMullen, A Ganguly, CA … - DIABETES, 2007 - Am Diabetes Assoc C ongenital hyperinsulinism (CHI) of infancy is characterized by inappropriate
insulin secretion in the face of severe hypoglycemia in neonates and infants
(1–4). Clinical treatments involving the use of diazoxide or somatostatin ... Related articles
- ►shouxi.net CW Lin, YW Lin, FF Yan, J Casey, M Kochhar, … - Diabetes, 2006 - Am Diabetes Assoc Heterozygous missense mutations in the pore-forming subunit Kir6.2 of
ATP-sensitive K + channels (K ATP channels) have recently been shown to cause
permanent neonatal diabetes mellitus (PNDM). Functional studies ... Cited by 12 - Related articles - BL Direct - All 5 versions
M Suchi, CM MacMullen, PS Thornton, NS … - Modern pathology, 2005 - nature.com Congenital hyperinsulinism is a rare pancreatic endocrine cell disorder that has
been categorized histologically into diffuse and focal forms. In focal
hyperinsulinism, the pancreas contains a focus of endocrine cell ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] FF Yan, YW Lin, C MacMullen, A Ganguly, CA … - Diabetes, 2007 - Am Diabetes Assoc Page 1. 1 Congenital hyperinsulinism-associated ABCC8 mutations that cause defective
trafficking of ATP-sensitive potassium channels: identification and rescue ... Cited by 1 - Related articles - All 2 versions
- ►nih.gov H de Wet, MG Rees, K Shimomura, J … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Gain-of-function mutations in the genes encoding the ATP-sensitive potassium (K
ATP ) channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) are a common cause of
neonatal diabetes mellitus. Here we investigate the molecular mechanism by ... Cited by 9 - Related articles - BL Direct - All 7 versions
SE Flanagan, S Clauin, C Bellanné-Chantelot, … - Hum Mutat, 2009 - interscience.wiley.com The beta-cell ATP-sensitive potassium (K ATP ) channel is a key component of
stimulus-secretion coupling in the pancreatic beta-cell. The channel couples
metabolism to membrane electrical events bringing about insulin secretion. ... Cited by 4 - Related articles - All 3 versions
- ►pedpath.org RM Greer, J Shah, YW Jeske, D Brown, RM … - Pediatric and Developmental Pathology, 2007 - pedpath.org In hyperinsulinism of infancy (HI), unregulated insulin secretion causes
hypoglycemia. Pancreatectomy may be required in severe cases, most of which
result from a defect in the β-cell K ATP channel, encoded by ABCC8 and ... Cited by 4 - Related articles - All 2 versions
SE Pinney, C MacMullen, S Becker, YW Lin, C … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov Congenital hyperinsulinism is a condition of dysregulated insulin secretion
often caused by inactivating mutations of the ATP-sensitive K + (K ATP ) channel
in the pancreatic β cell. Though most disease-causing mutations of the 2 ... Cited by 12 - Related articles - All 6 versions
