- ►diabetesjournals.org JA Ehses, A Perren, E Eppler, P Ribaux, JA Pospisilik, … - Diabetes, 2007 - Am Diabetes Assoc Activation of the innate immune system in obesity is a risk factor for the development of type 2
diabetes. The aim of the current study was to investigate the notion that increased numbers of
macrophages exist in the islets of type 2 diabetes patients and that this may be explained ... Cited by 49 - Related articles - BL Direct - All 11 versions
- ►endojournals.org MY Donath, J Storling, LA Berchtold, N Billestrup, T … - Endocrine …, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro discovery in 1984, evolving
via descriptive and phenomenological studies to detailed mapping of the signalling
pathways, gene- and protein expression patterns, molecular and biochemical effector ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►endojournals.org P Ribaux, JA Ehses, N Lin-Marq, F Carrozzino, M Boni- … - Endocrinology, 2007 - Endocrine Soc As we showed previously, the extracellular matrix (ECM) derived from rat bladder carcinoma
cells (804G-ECM) has positive effects on rat primary β-cell function and survival in vitro. The
aim of this study was to define β-cell genes induced by this ECM with a specific focus on ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org N Welsh, M Cnop, I Kharroubi, M Bugliani, R Lupi, P … - Diabetes, 2005 - Am Diabetes Assoc Different degrees of β-cell failure and apoptosis are present in type 1 and type 2 diabetes. It has
been recently suggested that high glucose–induced β-cell apoptosis in type 2 diabetes shares
a final common pathway with type 1 diabetes, involving interleukin-1β (IL-1β) production ... Cited by 40 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org F Homo-Delarche, S Calderari, JC Irminger, MN … - Diabetes, 2006 - Am Diabetes Assoc The molecular pathways leading to islet fibrosis in diabetes are unknown. Therefore, we studied
gene expression in islets of 4-month-old Goto-Kakizaki (GK) and Wistar control rats. Of 71 genes
found to be overexpressed in GK islets, 24% belong to extracellular matrix (ECM)/cell ... Cited by 45 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org S Weksler-Zangen, I Raz, S Lenzen, A Jörns, S … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Hyperglycemic Cohen diabetes–sensitive rats exhibited reduced pancreatic weight
with lipid deposits and interleukin-1β–positive macrophage infiltration in the exocrine
pancreas. Islet morphology was preserved, and total pancreatic insulin content did not ... Cited by 9 - Related articles - BL Direct - All 3 versions
- ►jhsph.edu [PDF] CM Larsen, M Faulenbach, A Vaag, A … - The New England …, 2007 - nejm.highwire.org Methods In this double-blind, parallel-group trial involving 70 patients with type 2 diabetes, we
randomly assigned 34 patients to receive 100 mg of anakinra (a recombinant human
interleukin-1–receptor antagonist) subcutaneously once daily for 13 weeks and 36 ... Cited by 144 - Related articles - BL Direct - All 12 versions
[CITATION] IL-1β expression is induced by glucose and IL-1β auto-stimulation and increased …
K Maedler, P Sergeev, JA Ehses, Z … - Proceedings of the …, 2004 - National Acad Sciences High concentrations of glucose induce β cell production of IL-1β, leading to impaired β cell function
and apoptosis in human pancreatic islets. IL-1 receptor antagonist (IL-1Ra) is a naturally occurring
antagonist of IL-1β and protects cultured human islets from glucotoxicity. Therefore, the ... Cited by 82 - Related articles - BL Direct - All 13 versions
- ►diabetesjournals.org K Maedler, DM Schumann, N Sauter, H Ellingsgaard, D … - Diabetes, 2006 - Am Diabetes Assoc High glucose concentrations have a dual effect on β-cell turnover, inducing proliferation in the
short-term and apoptosis in the long-term. Hyperglycemia leads to β-cell production of interleuking
(IL)-1β in human pancreatic islets. Fas, a death receptor regulated by IL-1β, is involved in ... Cited by 31 - Related articles - BL Direct - All 4 versions
