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Screening for insulitis in adult autoantibody-positive organ donors

- diabetesjournals.org
P In't Veld, D Lievens, J De Grijse, Z Ling, B Van der … - Diabetes, 2007 - Am Diabetes Assoc
Antibodies against islet cell antigens are used as predictive markers of type 1 diabetes, but it
is unknown whether they reflect an ongoing autoimmune process in islet tissue. We investigated
whether organs from adult donors that are positive for autoantibodies (aAbs) against islet ...
Cited by 12 - Related articles - BL Direct - All 4 versions

SCREENING FOR INSULITIS IN ADULT AUTOANTIBODY-POSITIVE ORGAN …


BVAMD PhD, MPMMD PhD, F Gorus, DP PhD, MD … - Am Diabetes Assoc
Peter In't Veld PhD, Dirk Lievens MSc, Joeri De Grijse MSc, Zhidong Ling MD PhD, Bart Van
der Auwera MD PhD, Miriam Pipeleers-Marichal MD PhD, Frans Gorus MD PhD, Daniel Pipeleers
MD PhD. ... Diabetes Research Center, Brussels Free University (VUB) and JDRF Center ...
Related articles

[PDF] Screening for Insulitis in Adult Autoantibody-Positive Organ Donors


M Pipeleers-Marichal, F Gorus, D Pipeleers - DIABETES, 2007 - Am Diabetes Assoc
Antibodies against islet cell antigens are used as predictive markers of type 1 diabetes, but it
is unknown whether they reflect an ongoing autoimmune process in islet tissue. We investigated
whether organs from adult donors that are positive for autoantibodies (aAbs) against islet ...
Related articles

Islet antigen specific IL-10+ immune responses but not CD4+ CD25+ FoxP3+ cells …


S Sanda, BO Roep, M von Herrath - Clinical Immunology, 2008 - Elsevier
The immune phenotype of the partial remission phase or “honeymoon phase” of type 1 diabetes
is not well defined. We compared flow cytometry and cytokine production by ELISPOT assays
in children with newly diagnosed type 1 diabetes and children in the partial remission ...
Cited by 7 - Related articles - All 2 versions

Islet β-Cell Death—Fuel to Sustain Autoimmunity?


CM Filippi, MG von Herrath - Immunity, 2007 - Elsevier
The notion that it indeed “matters how you die” has been investigated by numerous research
groups interested in autoimmune disorders. Cell death may result in either tolerance or enhanced
autoimmunity, and in type 1 diabetes (T1D), evidence has been found for both scenarios. ...
Cited by 8 - Related articles - All 3 versions

Viral Trigger for Type 1 Diabetes


CM Filippi, MG von Herrath - Diabetes, 2008 - Am Diabetes Assoc
The most popular hypothesis circulating within and beyond the scientific community is that viral
infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed, viruses can
injure β-cells and have been isolated in pancreatic tissues from diabetic patients. ...
Cited by 8 - Related articles - All 8 versions

Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and …


P Gao, Y Jiao, Q Xiong, CY Wang, I Gerling, … - Current …, 2008 - pubmedcentral.nih.gov
A systematic study has been conducted of all available reports in PubMed and OMIM (Online
Mendelian Inheritance in Man) to examine the genetic and molecular basis of quantitative genetic
loci (QTL) of diabetes with the main focus on genes and polymorphisms. The major ...
Related articles - All 4 versions

Autoimmune diabetes in adults: lessons from the UKPDS


M Desai, A Clark - Diabetic Medicine, 2008 - interscience.wiley.com
Latent autoimmune diabetes in adults (LADA) is characterised by a relatively mild diabetes
onset, autoantibody positivity and eventual requirement for insulin therapy. Twelve per cent of
newly diagnosed, UK Prospective Diabetes Study (UKPDS) patients were positive for ...
Related articles - All 3 versions

First-trimester human fetal pancreas transplantation for type 1 diabetes treatment: …


G Fousteri, M von Herrath - Diabetes, 2008 - Am Diabetes Assoc
Type 1 diabetes results from immune-mediated destruction of insulin-producing β-cells of the
pancreas. The disease manifests itself symptomatically when the resident β-cells become unable
to maintain normoglycemia. In human insulitis, mainly CD8 lymphocytes and B-cells, but ...
Related articles - BL Direct - All 3 versions

Detection of enteroviruses in the intestine of type 1 diabetic patients


M Oikarinen, S Tauriainen, T Honkanen, S … - Clinical and …, 2008 - pubmedcentral.nih.gov
Enterovirus infections have been diagnosed more frequently in type 1 diabetic patients than
in the healthy population, and enteroviruses have also been found in the pancreas of diabetic
patients. Primary replication of the virus occurs in the gut, but there are no previous ...
Cited by 13 - Related articles - BL Direct - All 4 versions


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